Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort
Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort
复制标题
DOI：
10.2147/clep.s151613
复制
发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Hagstromer, Maria
中科院分区：
文献类型：
--
作者：
Dohrn, Ing-Mari;Kwak, Lydia;Hagstromer, Maria
背景：久坐行为与成年人的健康风险有关。减少久坐时间的潜在好处可能不仅取决于减少本身，还取决于它所取代的活动类型。很少有纵向研究调查了用另一种体力活动（PA）行为替代客观评估的久坐时间对死亡率的影响。目的：调查在15年随访时间的队列中，用轻强度PA或中等强度PA（MVPA）时间替代客观评估的久坐时间对全因死亡率、心血管疾病（CVD）死亡率或癌症死亡率的影响。方法：总共有851名来自瑞典人口态度行为和变化研究的妇女和男子被纳入其中。使用Actigraph 7164加速度计评估久坐、光强度PA和MVPA的时间。死亡率数据来自瑞典登记册。考克斯比例风险模型估计死亡率的风险比（HR），95%置信区间（CI）和等时替代模型用于估计在相同时间内用PA替代久坐行为的效果。在14.2年（SD 1.9）的随访中，有12，117人-年处于风险中，79人死亡，24人死于CVD，27人死于癌症，28人死于其他原因。用光强度PA替代30分钟/天的久坐时间与全因死亡风险（HR：0.89，95% CI：0.81-0.98）和CVD死亡风险（HR：0.76，95% CI：0.63-0.92）显著降低相关。用MVPA代替10分钟的久坐时间与CVD死亡风险降低相关（HR：0.62，95% CI：0.42-0.91）。没有统计学显着减少被发现为cancer mortality.Conclusion：这个统计建模研究表明，取代久坐不动的时间与光强度PA可能有有益的影响，对所有原因的死亡率和CVD死亡率。用MVPA代替久坐时间可以降低CVD死亡率。
Background: Sedentary behavior is associated with health risks in adults. The potential benefits of reducing sedentary time may be dependent not only on decrease per se, but also on the type of activity it replaces. Few longitudinal studies have investigated the effects on mortality when replacing objectively assessed sedentary time with another physical activity (PA) behavior.Objective: To investigate the effects of replacing objectively assessed sedentary time with time in light-intensity PA or moderate-vigorous PA (MVPA) on all-cause mortality, cardiovascular disease (CVD) mortality or cancer mortality in a cohort with 15 years follow-up time.Methods: In total, 851 women and men from the population-based Sweden Attitude Behaviour and Change study were included. Time spent sedentary, in light-intensity PA and in MVPA were assessed using an Actigraph 7164 accelerometer. Mortality data were obtained from Swedish registers. Cox proportional hazards models estimated hazard ratios (HR) of mortality with 95% confidence intervals (CI) and isotemporal substitution models were used to estimate the effect of replacing sedentary behavior with PA for the same amount of time.Results: Over a follow-up of 14.2 years (SD 1.9) with 12,117 person-years at risk, 79 deaths occurred, 24 deaths from CVD, 27 from cancer, and 28 from other causes. Replacing 30 minutes/day of sedentary time with light-intensity PA was associated with significant reduction in all-cause mortality risk (HR: 0.89, 95% CI: 0.81-0.98) and CVD mortality risk (HR: 0.76, 95% CI: 0.63-0.92). Replacing 10 minutes of sedentary time with MVPA was associated with reduction in CVD mortality risk (HR: 0.62, 95% CI: 0.42-0.91). No statistically significant reductions were found for cancer mortality.Conclusion: This statistical modelling study suggests that replacing sedentary time with light-intensity PA could have beneficial effect on both all-cause mortality and CVD mortality. Replacing sedentary time with MVPA could reduce CVD mortality.