Androgen levels in the third trimester of pregnancy in patients with preeclampsia
Androgen levels in the third trimester of pregnancy in patients with preeclampsia
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DOI：
10.1016/j.ejogrb.2005.07.007
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发表时间：
2006-05-01
影响因子：
2.6
通讯作者：
Creatsas, Georgios
中科院分区：
文献类型：
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作者：
Salamalekis, Emanouel;Bakas, Panagiotis;Creatsas, Georgios
目的：为了研究子痫前期患者的睾酮水平是否高于血压正常的孕妇patients.Study design：在妊娠晚期对28例确诊子痫前期的患者和25例血压正常的妇女进行血清总睾酮和游离睾酮、硫酸脱氢表雄酮、雄烯二酮和性激素结合球蛋白水平的评估。两组之间在母亲年龄、胎龄、体重指数（BMI）、红细胞压积和新生儿性别方面无统计学显著差异。平均值+/- S.D.子痫前期组总睾酮和游离睾酮水平显著高于对照组（P < 0.01）。DHEA-S，雄烯二酮和性激素结合球蛋白的值较低的子痫前期组，但差异没有达到统计学意义。结论（S）：总睾酮和游离睾酮的水平似乎是较高的子痫前期患者相比，血压正常的孕妇在妊娠晚期。这种差异可能表明睾丸激素参与先兆子痫的病理生理学，并刺激研究抗雄激素在先兆子痫管理中的潜在作用。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients.Study design: The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women.Results: No statistically significant differences were noted between the two groups regarding the maternal age, gestational age, body mass index (BMI) haematocrit and neonatal sex. The mean +/- S.D. total testosterone and free testosterone levels were significantly higher (p < 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance.Conclusion(s): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia. (C) 2005 Elsevier Ireland Ltd. All rights reserved.