Digital tomosynthesis of the chest: Utility for detection of lung metastasis in patients with colorectal cancer
Digital tomosynthesis of the chest: Utility for detection of lung metastasis in patients with colorectal cancer
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DOI：
10.1016/j.crad.2011.08.017
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发表时间：
2012-03-01
影响因子：
2.6
通讯作者：
Lee, K. S.
中科院分区：
文献类型：
--
作者：
Jung, H. N.;Chung, M. J.;Lee, K. S.
目的：评价胸部数字断层合成（DT）对结直肠癌（CRC）患者肺结节的检测价值。材料和方法：机构审查委员会批准了这项研究，所有患者都提供了知情同意。使用商用的碘化铯/非晶硅（CsI/ A - si）平板探测器系统来验证DT和胸部x线摄影（XR）方法的性能。对142例结直肠癌患者行DT治疗。所有142例患者在DT后一周内均行胸部CT检查。作为参考标准，两名放射科医师一致复查胸部CT，记录肺结节的存在。另外两名放射科医生独立观察了DT图像并记录了肺结节的存在。通过组织学或1年的随访评估所有肺结节的状态。结节分为转移性、良性和不确定。对结果进行统计分析。结果：142例患者CT检查发现结节237例。其中71例确诊转移瘤和126例良性结节；40个结节不确定。观察人员使用DT检测出83%的肺结节和93%的确诊转移灶。237个结节中，CT影像上直径大于4mm的结节147个。结论：尽管辐射剂量相对较低，但DT是一种敏感的方法，在检测肺结节，特别是CRC患者的转移性肺结节方面与胸部CT相当。(C) 2011年英国皇家放射学院。Elsevier Ltd.出版。版权所有。
AIM: To evaluate the performance of digital tomosynthesis (DT) of the chest for detection of lung nodules in patients with colorectal cancer (CRC).MATERIALS AND METHODS: The institutional review board approved this study, and all patients provided informed consent. A commercial caesium iodide/amorphous silicon (CsI/a-Si) flat-panel detector system was used to verify the performance of the DT and chest radiography (XR) methods. DT was performed in 142 patients with CRC. All 142 patients underwent chest computed tomography (CT) within a week of DT. As a reference standard, two radiologists reviewed the chest CT in consensus and recorded the presence of pulmonary nodules. Another two radiologists independently observed the DT images and recorded the presence of pulmonary nodules. The status of all lung nodules was assessed either histologically or by follow-up over a period of 1 year. The nodules were classified into metastasis, benign, and uncertain. Statistical analysis of the results was performed.RESULTS: Two hundred and thirty-seven nodules from 142 patients were found at CT. These included 71 proven metastases and 126 benign nodules; 40 nodules were uncertain. Observers detected 83% of all lung nodules and 93% of proven metastases using DT. Among 237 nodules, 147 nodules were larger than 4 mm in diameter on the CT images. Observers detected 87% of lung nodules that were larger than 4 mm.CONCLUSION: Despite a reasonably low radiation dose, DT is a sensitive method, and is comparable to chest CT for the detection of lung nodules, particularly metastatic lung nodules in patients with CRC. (C) 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.