The diagnostic value of endothelial function as a potential sensor of fatigue in health.
The diagnostic value of endothelial function as a potential sensor of fatigue in health.
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DOI：
10.2147/vhrm.s8950
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发表时间：
2010-03-24
影响因子：
2.9
通讯作者：
Maruyama I
中科院分区：
文献类型：
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作者：
Ohno Y;Hashiguchi T;Maenosono R;Yamashita H;Taira Y;Minowa K;Yamashita Y;Kato Y;Kawahara K;Maruyama I
许多流行病学研究表明，生命衰竭和心理社会因素与心血管疾病（CCVD）的发生有关。疲劳被认为会诱导内皮功能障碍，并可能与CCVD的发生有关;然而，没有研究调查这种潜在的联系。我们研究了疲劳对健康受试者内皮功能的影响，没有传统的CCVD危险因素或潜在的混杂因素需要控制。外周动脉张力测定（PAT）用于评估内皮功能。对74名健康体检时无传统CCVD危险因素的上班族进行了以下参数对内皮功能的影响分析：工作前后的内皮功能，主观疲劳，生活方式因素如睡眠时间，心理社会因素如抑郁和社会支持。25名受试者（33.8%）具有低内皮功能;反应性充血（RH）-PAT指数<1.67，尽管健康检查中未报告异常。分娩前后内皮功能无显著差异。值得注意的是，内皮功能与个体的主观疲劳水平相关（t = 2.98，P = 0.008），并且显示出每日波动，有时达到病理程度（<1.67）。我们发现，即使在健康人中，内皮功能也会随着个体认知疲劳和环境之间的相互作用而每日波动，有时达到病理程度。基于这些发现，我们认为内皮功能是健康个体疲劳的客观评估工具。
Many epidemiological research studies have shown that vital exhaustion and psychosocial factors are associated with the occurrence of cerebrocardiovascular disease (CCVD). Fatigue is thought to induce endothelial dysfunction and may be linked to the occurrence of CCVD; however, no studies have investigated this potential link. We studied to determine the effect of fatigue on endothelial function in healthy subjects with no traditional CCVD risk factors or potential confounding factors to be controlled. Peripheral arterial tonometry (PAT) was used to evaluate endothelial function. The influence of the following parameters on endothelial function was analyzed in 74 office workers without traditional CCVD risk factors at health check-ups: endothelial function before and after work, subjective fatigue, lifestyle factors such as sleeping time, and psychosocial factors such as depression and social support. Twenty-five subjects (33.8%) had low endothelial function; reactive hyperemia (RH)-PAT index <1.67, even though no abnormalities were reported in the health check-ups. There was no significant difference in endothelial function before versus after labor. Of note, endothelial function was associated with the individual’s level of subjective fatigue (t = 2.98, P = 0.008) and showed a daily fluctuation, sometimes to a pathological degree (<1.67). We showed that, even in healthy people, endothelial function fluctuates diurnally, with an interaction between the individual’s cognitive fatigue and the environment, sometimes to a pathological degree. Based on these findings, we suggest that endothelial function is an objective assessment tool of fatigue in healthy individuals.