Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility
Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility
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DOI：
10.1155/2010/305192
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发表时间：
2010-03
期刊：
影响因子：
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通讯作者：
M. Fujimiya;A. Asakawa;K. Ataka;Chih‐Yen Chen;I. Kato;A. Inui
中科院分区：
文献类型：
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作者：
M. Fujimiya;A. Asakawa;K. Ataka;Chih‐Yen Chen;I. Kato;A. Inui
生长素释放肽、去酰基生长素释放肽和肥胖抑制素通过翻译后加工源自于共同的激素原，前生长素释放肽原，其源自于胃中的内分泌细胞。为了研究这些肽的调节作用，我们在自由活动的清醒大鼠或小鼠模型中应用了胃肠动力的测压测量。Ghrelin在进食和禁食状态下对动物胃窦和十二指肠的运动都有刺激作用。在禁食状态下，去酰基ghrelin对动物胃窦运动有抑制作用，但对十二指肠运动无抑制作用。Obestatin对动物进食状态下的胃窦和十二指肠运动有抑制作用，但对禁食状态下的胃窦和十二指肠运动无抑制作用。脑中的NPY Y2和Y4受体可介导ghrelin的作用，脑中的CRF 2型受体可介导去酰基ghrelin的作用，而脑中的CRF 1型和2型受体可介导obestatin的作用。迷走神经传入通路可能参与ghrelin的作用，但不参与去酰基ghrelin的作用，而迷走神经传入通路可能部分参与obestatin的作用。
Ghrelin, des-acyl ghrelin, and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the regulatory roles of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat or mouse model. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin.