Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.
Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.
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DOI：
10.1016/j.addr.2015.12.016
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发表时间：
2016-02-01
影响因子：
16.1
通讯作者：
Kyriakides TR
中科院分区：
文献类型：
--
作者：
Sawyer AJ;Kyriakides TR
细胞外基质由复杂的分子阵列组成，这些分子共同为细胞提供结构和功能支持。这些特性主要由胶原纤维、弹性纤维、蛋白聚糖以及纤连蛋白和层粘连蛋白等蛋白质的活性介导。 ECM 成分是组织特异性的，可能包括基质细胞蛋白，其主要作用是调节细胞-基质相互作用。在成人中，基质细胞蛋白主要在损伤、炎症和疾病期间表达。特别是，它们与心血管和纤维化疾病以及癌症的进展和预后密切相关。本综述旨在概述基质细胞蛋白在药物递送中的潜在用途，包括根据这些蛋白质的性质和结构生成治疗剂以及它们作为特定疾病生物标志物的用途。
Extracellular matrix is composed by a complex array of molecules that together provide structural and functional support to cells. These properties are mainly mediated by the activity of collagenous and elastic fibers, proteoglycans, and proteins such as fibronectin and laminin. ECM composition is tissue-specific and could include matricellular proteins whose primary role is to modulate cell-matrix interactions. In adults, matricellular proteins are primarily expressed during injury, inflammation and disease. Particularly, they are closely associated with the progression and prognosis of cardiovascular and fibrotic diseases, and cancer. This review aims to provide an overview of the potential use of matricellular proteins in drug delivery including the generation of therapeutic agents based on the properties and structures of these proteins as well as their utility as biomarkers for specific diseases.