REGIONAL CEREBRAL BLOOD-FLOW IN DEPRESSION MEASURED BY POSITRON EMISSION TOMOGRAPHY - THE RELATIONSHIP WITH CLINICAL DIMENSIONS
REGIONAL CEREBRAL BLOOD-FLOW IN DEPRESSION MEASURED BY POSITRON EMISSION TOMOGRAPHY - THE RELATIONSHIP WITH CLINICAL DIMENSIONS
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DOI：
10.1017/s0033291700025368
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发表时间：
1993-08-01
影响因子：
6.9
通讯作者：
DOLAN, RJ
中科院分区：
文献类型：
--
作者：
BENCH, CJ;FRISTON, KJ;DOLAN, RJ
我们之前曾报告过33名重度抑郁症患者的局部脑血流（rCBF）局灶性异常。这份报告，对40例患者的扩展样本谁表现出相同的区域赤字，以那些先前描述的，探讨抑郁症状和模式的rCBF之间的关系。患者的症状评级进行因素分析，产生三因素的解决方案。这三个因素的得分，对应于抑郁症的可识别维度，然后与rCBF相关。第一个因素有高负荷的焦虑和正相关的rCBF在后扣带皮层和顶下小叶双边。第二个因素有高负荷的精神发育迟滞和抑郁情绪，并与左背外侧前额叶皮层和左角回的rCBF呈负相关。第三个因素有一个高负荷的认知性能和正相关的rCBF在左内侧前额叶皮层。这些数据表明，症状特异性可能归因于区域功能缺陷的重性抑郁症。
We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.