SPONTANEOUS MURINE B-CELL LEUKEMIA
SPONTANEOUS MURINE B-CELL LEUKEMIA
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DOI：
10.1038/272624a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
STROBER, S
中科院分区：
文献类型：
--
作者：
SLAVIN, S;STROBER, S
胸腺来源(T)和骨髓来源(B)的细胞表面标记在正常淋巴细胞群体中的发现导致了对各种人类和小鼠淋巴样肿瘤的细胞谱系和分化途径的广泛研究。小鼠的大多数自发性淋巴瘤和淋巴细胞性白血病是T淋巴细胞系的成员1。虽然在小鼠中已有B淋巴细胞肿瘤的报道，但这些肿瘤是用致癌物质或Abelson病毒2-5诱导的。我们在这里报告了一种源于BALB/小鼠并在其体内传代的自发性B细胞白血病的特征。这种肿瘤似乎类似于人类慢性淋巴细胞白血病(CLL)，并可能为这种疾病的研究提供一个有用的模型。
THE discovery of thymus-derived (T) and bone marrow-derived (B) specific cell-surface markers in normal lymphocyte populations led to extensive studies of the cell lineage and differentiation pathways of various human and murine lymphoid neoplasms. Most spontaneous lymphomas and lymphocytic leukaemias in mice are members of the T-lymphocyte lineage1. Although B-lymphocyte tumours have been reported in mice, these neoplasms were induced experimentally, using carcinogens or Abelson virus2–5. We report here the characteristics of a spontaneous B-cell leukaemia derived from, and passaged in BALB/mice. This tumour seems to be analogous to human chronic lymphocyte leukaemia (CLL), and may provide a useful model for the study of this disease.