The linear Behavior of the system middle cerebral artery flow velocity and blood pressure in patients with migraine -: Lack of autonomic control?
The linear Behavior of the system middle cerebral artery flow velocity and blood pressure in patients with migraine -: Lack of autonomic control?
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DOI：
10.1161/01.str.0000177886.94134.92
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发表时间：
2005-09-01
期刊：
影响因子：
8.3
通讯作者：
Marziniak, M
中科院分区：
文献类型：
--
作者：
Müller, M;Marziniak, M
背景和目的 - 偏头痛被认为是一种自主神经系统疾病。我们使用动态脑自动调节的频率分析来评估是否可以在存在交感神经和副交感神经活动的频率上发现血流调节障碍。方法 - 我们使用经颅多普勒超声同时测量了 33 名健康对照者（平均年龄 +/- SD；36 +/- 13 岁）和 22 名偏头痛患者（平均年龄；39 岁）的大脑中动脉平均动脉血压 (BP) 和平均血流速度 (V)。 +/- 7 年）。除了评估 BP 和 V 的频谱功率密度外，我们还计算了 0.0 至 0.25 Hz 频率范围内的传递函数参数增益、相位和相干性。结果 - 与对照组相比，偏头痛患者中 BP 和 V 的频谱功率密度的最大值为 1026，而对照组中 BP 和 V 的最大值为 10(-3)。一致性显示患者和对照之间没有差异。对照组中 BP 和 V 之间的增益增加 >0.01 Hz，但偏头痛患者在整个频率范围内接近 0 或负值（P
Background and Purpose - Migraine is considered a disorder of the autonomic nervous system. We used the frequency analysis of dynamic cerebral autoregulation to assess whether blood flow regulation disturbances can be found at the frequencies at which sympathetic and parasympathetic activity is present.Methods - We measured simultaneously mean arterial blood pressure (BP) and the mean blood velocity (V) in the middle cerebral artery using transcranial Doppler ultrasound in 33 healthy controls (mean age +/- SD; 36 +/- 13 years) and in 22 patients with migraine (mean age; 39 +/- 7 years). Apart from assessing spectral power density for BP and V, we calculated the transfer function parameters gain, phase, and coherence at the frequency range between 0.0 and 0.25 Hz.Results - Compared with the controls, the spectral power density of BP and V exhibited a maximum magnitude of 1026 in the migraine patients, whereas the maximum magnitude of BP and V in the controls was 10(-3). Coherence showed no difference between patients and controls. Gain between BP and V increased in the controls >0.01 Hz but was approximate to 0 or negative in the migraine patients over the whole frequency range (P