GENETIC RESCUE OF INVIABLE HYBRIDS BETWEEN DROSOPHILA-MELANOGASTER AND ITS SIBLING SPECIES
GENETIC RESCUE OF INVIABLE HYBRIDS BETWEEN DROSOPHILA-MELANOGASTER AND ITS SIBLING SPECIES
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DOI：
10.1038/327331a0
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发表时间：
1987-05-28
期刊：
影响因子：
64.8
通讯作者：
ASHBURNER, M
中科院分区：
文献类型：
--
作者：
HUTTER, P;ASHBURNER, M
交配后机制对于在不同但密切相关的物种之间建立生殖隔离至关重要。交配后隔离机制包括杂交破坏、杂交不育和杂交致死1,2，并且在某些情况下，可能通过行为学分化等交配前机制得到加强。在果蝇物种亚群中，交配后生殖隔离是通过杂种的不存活性和不育性来确保的。例如，当雌性黑腹果蝇与雄性果蝇杂交时，杂交后代通常都是雌性；杂交雄性在第三龄幼虫时死亡4-6。可存活的杂交雌性是完全不育的4,5。尽管Coyne等人7,8已经开始对该物种亚群内的杂种不育性进行遗传分析，但对于杂种不育或杂种不育的遗传基础知之甚少。我们发现了一个单一的基因差异，可以从黑腹果蝇雌性与其三个近亲的雄性之间的杂交中拯救出原本无法生存的雄性杂种。该基因座的研究可能有助于揭示物种形成和发育的遗传控制。
Post-mating mechanisms are central to the establishment of reproductive isolation between different, but closely related, species. Post-mating isolation mechanisms include hybrid breakdown, hybrid sterility and hybrid lethality1,2and may, in some cases, be reinforced by pre-mating mechanisms such as ethological differentiation. In theDrosophila melanogasterspecies sub-group post-mating reproductive isolation is ensured by both the inviability and the sterility of hybrids3. For example whenD.melanogasterfemales are crossed toD.simulansmales the hybrid progeny are normally all female; the hybrid males die as third instar larvae4–6. The viable hybrid females are totally sterile4,5. Little is known of the genetic basis for either hybrid sterility or hybrid inviability, although Coyne and others7,8have begun a genetic analysis of the sterility of hybrids within this species sub-group. We have discovered a single gene difference that rescues the otherwise inviable male hybrids from the cross betweenD.melanogasterfemales and males of its three closest relatives. The study of this locus may shed light on the genetic control of both speciation and development.