7-nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains.
7-nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains.
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A/J 和 C57BL/6J 小鼠品系的 7-硝基吲唑和缺氧后通气行为。
DOI：
10.1152/japplphysiol.00166.2003
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Strohl,KingmanP
中科院分区：
文献类型：
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作者：
Price,EdwinR;Han,Fang;Dick,ThomasE;Strohl,KingmanP
Periodic breathing (PB) is a fundamental breathing pattern in many common cardiopulmonary illnesses. The finding of PB in C57BL/6J (B6) mice was previously ascribed to strain differences in posthypoxic ventilatory and frequency decline in the B6 mice (Han F, Subramanian S, Price ER, Nadeau J, and Strohl KP.J Appl Physiol92: 1133-1140, 2002). We tested whether the induction of posthypoxic frequency decline in A/J mice, through administration of a neuronal nitric oxide synthase blocker [7-nitroindazole (7-NI); 60 mg/kg], would cause A/J mice to exhibit PB and/or alter PB expression in the B6 strain. Recordings of ventilatory behavior by the plethysmography method were made when unanesthetized B6 (n= 10) or A/J (n= 6) animals were reoxygenated with 100% O2or room air after exposure to 8% O2. Before undergoing gas challenges, mice were given an intraperitoneal injection of either peanut oil alone (vehicle) or 7-NI suspended in peanut oil. Compared with vehicle, both strains of mice exhibited posthypoxic frequency decline and the absence of short-term potentiation with 7-NI administration. B6 mice continued to exhibit posthypoxic PB; however, the PB was characterized by longer cycle and apnea length. In contrast, A/J mice did not show increased tendency toward posthypoxic PB with 7-NI. We conclude that 7-NI further differentiates the A/J and B6 strains in terms of PB and that strain-related differences in posthypoxic frequency decline are not primary determinants of this strain difference in the occurrence of PB. Metabolism was not associated with either the expression of posthypoxic ventilatory decline or PB. Furthermore, neuronal nitric oxide may be an organizing feature in the presence, length, and/or cycle length of apnea in the susceptible strain.
