Sex-dependent fear memory impairment in cocaine-sired rat offspring.
Sex-dependent fear memory impairment in cocaine-sired rat offspring.
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DOI：
10.1126/sciadv.adf6039
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发表时间：
2023-10-20
期刊：
影响因子：
13.6
通讯作者：
Pierce, R. Christopher
中科院分区：
文献类型：
--
作者：
Rich, Matthew T.;Worobey, Samantha J.;Mankame, Sharvari;Pang, Zhiping P.;Swinford-Jackson, Sarah E.;Pierce, R. Christopher
雄性大鼠自我施用可卡因导致后代的神经元和行为改变，包括对可卡因的反应。考虑到可卡因和压力的病理反应背后的大脑系统之间的高度重叠，我们研究了父系可卡因服用是否会影响药物初治的成年男性和女性后代的恐惧相关行为效应。陛下可卡因暴露没有影响上下文的恐惧条件反射或其灭绝的男性或女性后代。在线索恐惧条件反射，冻结行为增强女性，但不是男性，可卡因sired后代。与此相反，男性可卡因sired后代表现出增强的线索条件下的恐惧在灭绝的表达。长时程增强（LTP）是强大的基底外侧杏仁核（BLA），其中编码恐惧条件反射，雌性后代，但完全没有可卡因暴露的公畜的雄性后代。总的来说，这些结果表明，提示的恐惧记忆是增强可卡因暴露的公畜，这也有BLA突触可塑性缺陷的男性后代。可卡因暴露大鼠雄性后代的恐惧记忆增强。
Cocaine self-administration by male rats results in neuronal and behavioral alterations in offspring, including responses to cocaine. Given the high degree of overlap between the brain systems underlying the pathological responses to cocaine and stress, we examined whether sire cocaine taking would influence fear-associated behavioral effects in drug-naïve adult male and female progeny. Sire cocaine exposure had no effect on contextual fear conditioning or its extinction in either male or female offspring. During cued fear conditioning, freezing behavior was enhanced in female, but not male, cocaine-sired progeny. In contrast, male cocaine-sired progeny exhibited enhanced expression of cue-conditioned fear during extinction. Long-term potentiation (LTP) was robust in the basolateral amygdala (BLA), which encodes fear conditioning, of female offspring but was completely absent in male offspring of cocaine-exposed sires. Collectively, these results indicate that cued fear memory is enhanced in the male progeny of cocaine exposed sires, which also have BLA synaptic plasticity deficits. Cued fear memory is enhanced in the male progeny of cocaine-exposed rat sires.
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