Thymoma production of T cell growth factor (Interleukin 2).
Thymoma production of T cell growth factor (Interleukin 2).
复制标题
胸腺瘤产生 T 细胞生长因子（白细胞介素 2）。
DOI：
10.4049/jimmunol.125.6.2555
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发表时间：
1980
影响因子：
4.4
通讯作者：
W. Farrar
中科院分区：
文献类型：
--
作者：
J. Farrar;J. Fuller;P. Simon;M. Hilfiker;B. Stadler;W. Farrar
佛波醇-12-肉豆蔻酸酯-13-乙酸酯刺激小鼠EL-4胸腺瘤细胞亚系在体外以非常高的滴度产生T细胞生长因子（白细胞介素2，IL 2）。EL-4衍生的IL 2具有相同的分子量。(30 000）和等电点异质性（pI 3.8-4.4）。此外，胸腺瘤来源的IL 2表现出与脾细胞来源的IL 2相同的生物活性谱。
Phorbol-12-myristate-13-acetate stimulates a subline of mouse EL-4 thymoma cells to produce, in vitro, in very high titer, T cell growth factor (Interleukin 2, IL 2). The EL-4-derived IL 2 has the same m.w. (30,000) and isoelectric point heterogeneity (pI 3.8-4.4) as the IL 2 produced by Con A-stimulated spleen cells. In addition, the thymoma-derived IL 2 exhibits the same spectrum of biologic activities as has been reported for spleen cell-derived IL 2.