Cortical Auditory Evoked Potentials Recorded From Nucleus Hybrid Cochlear Implant Users.
Cortical Auditory Evoked Potentials Recorded From Nucleus Hybrid Cochlear Implant Users.
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DOI：
10.1097/aud.0000000000000206
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发表时间：
2015-11
期刊：
影响因子：
3.7
通讯作者：
Abbas PJ
中科院分区：
文献类型：
--
作者：
Brown CJ;Jeon EK;Chiou LK;Kirby B;Karsten SA;Turner CW;Abbas PJ
Nucleus Hybrid CI用户通过声刺激听到低频声音，通过电刺激听到高频声音。本受试者内研究比较了混合器械声学和电气组件协调编程的三种不同方法。言语知觉和皮层听觉诱发电位（CAEP）被用来评估结果的差异。本研究的目的是确定（1）诱发电位测量是否可以预测哪种编程策略在语音感知任务上产生更好的结果或收听者更喜欢哪种编程策略，以及（2）CAEP是否可以用于预测哪些受试者从混合植入体提供的电信号中获益最多。从10名Nucleus Hybrid CI用户记录CAEP。使用三种不同的实验MAP对研究参与者进行测试，这些MAP在混合器械的声学组件处理的频率范围与电气组件处理的频率范围之间的重叠程度方面有所不同。研究设计包括允许参与者在言语感知和诱发电位测试之前适应每个实验程序长达4周的时间。使用实验地图的性能进行了评估，使用一个封闭的辅音识别任务和自适应测试，测量的信号噪声比，导致在50%的正确识别的一组12个spondees在背景噪声（SNR-50）。长持续时间，合成元音被用来记录皮层P1-N1-P2的“开始”反应和听觉“变化”或ACC反应。诱发电位的措施和性能的言语知觉任务之间的相关性的报告。使用三种方案拟订战略的业绩差别不大。AAC响应的峰到峰幅度没有被发现是足够敏感的，以准确地预测编程策略，导致在任何一个测量的语音感知的最佳性能。所有10名混合CI用户都有残余低频声学听力。对于所有10名受试者来说，允许他们使用植入物提供的声学和电信号改善了辅音识别任务的表现。对于大多数受试者来说，它也导致了稍大的皮质变化反应。然而，听力模式对皮层变化反应的影响很小，诱发电位和言语感知结果之间的相关性也不显著。CAEP可以从混合CI用户成功测量。所记录的响应类似于从正常听力收听者记录的响应。本研究的目的是，看看CAEP可能发挥作用，无论是在确定实验程序，导致最佳性能的辅音识别任务或记录受益于使用的混合CI提供的电信号。至少对于本研究中使用的刺激和特定方法，没有发现这种预测关系。
Nucleus Hybrid CI users hear low-frequency sounds via acoustic stimulation and high frequency sounds via electrical stimulation. This within-subject study compares three different methods of coordinating programming of the acoustic and electrical components of the Hybrid device. Speech perception and cortical auditory evoked potentials (CAEP) were used to assess differences in outcome. The goals of this study were to determine (1) if the evoked potential measures could predict which programming strategy resulted either in better outcome on the speech perception task or was preferred by the listener, and (2) whether CAEPs could be used to predict which subjects benefitted most from having access to the electrical signal provided by the Hybrid implant. CAEPs were recorded from 10 Nucleus Hybrid CI users. Study participants were tested using three different experimental MAPs that differed in terms of how much overlap there was between the range of frequencies processed by the acoustic component of the Hybrid device and range of frequencies processed by the electrical component. The study design included allowing participants to acclimatize for a period of up to 4 weeks with each experimental program prior to speech perception and evoked potential testing. Performance using the experimental MAPs was assessed using both a closed-set consonant recognition task and an adaptive test that measured the signal to noise ratio that resulted in 50% correct identification of a set of 12 spondees presented in background noise (SNR-50). Long-duration, synthetic vowels were used to record both the cortical P1-N1-P2 “onset” response and the auditory “change” or ACC response. Correlations between the evoked potential measures and performance on the speech perception tasks are reported. Differences in performance using the three programming strategies were not large. Peak-to-peak amplitude of the AAC response was not found to be sensitive enough to accurately predict the programming strategy that resulted in the best performance on either measure of speech perception. All 10 Hybrid CI users had residual low frequency acoustic hearing. For all 10 subjects, allowing them to use both the acoustic and electrical signals provided by the implant improved performance on the consonant recognition task. For most subjects, it also resulted in slightly larger cortical change responses. However, the impact that listening mode had on the cortical change responses was small and again, the correlation between the evoked potential and speech perception results was not significant. CAEPs can be successfully measured from Hybrid CI users. The responses that are recorded are similar to those recorded from normal hearing listeners. The goal of this study was to see if CAEPs might play a role either in identifying the experimental program that resulted in best performance on a consonant recognition task or documenting benefit from use of the electrical signal provided by the Hybrid CI. At least for the stimuli and specific methods used in this study, no such predictive relationship was found.