Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer.
Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer.
复制标题
原发性和转移性卵巢癌中的细胞色素P450 CYP1B1过表达。
DOI：
10.1054/bjoc.2001.1907
复制
发表时间：
2001-07-20
影响因子：
8.8
通讯作者：
Murray, G I
中科院分区：
文献类型：
--
作者：
McFadyen, M C;Cruickshank, M E;Miller, I D;McLeod, H L;Melvin, W T;Haites, N E;Parkin, D;Murray, G I
卵巢癌是全球妇科恶性肿瘤最常见的死亡原因。这种疾病的长期预后几乎没有改善，患者的5年生存率仅为30%。这种不良预后是由于疾病的晚期表现和卵巢癌对化疗的不可预测的反应。细胞色素P450酶是血红素蛋白的超家族，已知参与许多抗癌药物的代谢活化和/或解毒。CYP 1B 1是细胞色素P450的一种肿瘤相关形式，在不同组织学类型的多种原发性肿瘤中过度表达。CYP 1B 1的存在可能在这些肿瘤对抗癌药物的调节中具有重要意义。我们对原发性和转移性卵巢癌中细胞色素P450 CYP 1B 1的存在进行了全面的免疫组织化学研究。本研究的关键发现是CYP 1B 1在大多数研究的卵巢癌中表达增加（92%），原发性和转移性卵巢癌中CYP 1B 1表达之间表现出强相关性（P= 0.005斯皮尔曼等级相关检验）。而正常卵巢组织中未检测到CYP 1B 1。© 2001年癌症研究运动http://www.bjcancer.com
Ovarian cancer is the most frequent cause of death from gynaecological malignancies world wide. Little improvement has been made in the long-term outcome of this disease, with the 5-year survival of patients only 30%. This poor prognosis is due to the late presentation of the disease and to the unpredictable response of ovarian cancer to chemotherapy. The cytochrome P450 enzymes are a superfamily of haemoproteins, known to be involved in the metabolic activation and/or detoxification of a number of anti-cancer drugs. CYP1B1 is a tumour-related form of cytochrome P450 which is over expressed in a wide variety of primary tumours of different histological type. The presence of CYP1B1 may be of importance in the modulation of these tumours to anti-cancer drugs. We have conducted a comprehensive immunohistochemical investigation, into the presence of cytochrome P450 CYP1B1 in primary and metastatic ovarian cancer. The key findings of this study are the increased expression of CYP1B1 in the majority of ovarian cancers investigated (92%), with a strong correlation demonstrated between CYP1B1 expression in both primary and metastatic ovarian cancer (P= 0.005 Spearman's rank correlation test). In contrast no detectable CYP1B1 was found in normal ovary. © 2001 Cancer Research Campaign http://www.bjcancer.com