Analysis of HLA-DQB1 gene polymorphisms in asymptomatic HBV carriers and chronic hepatitis B patients in the Chinese Han population
Analysis of HLA-DQB1 gene polymorphisms in asymptomatic HBV carriers and chronic hepatitis B patients in the Chinese Han population
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DOI：
10.1111/j.1744-313x.2006.00607.x
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发表时间：
2006-08-01
影响因子：
2.2
通讯作者：
Hui, L.
中科院分区：
文献类型：
--
作者：
Xi-Lin, Z.;Te, D.;Hui, L.
宿主遗传因素和环境因素，包括乙肝病毒(乙肝病毒)基因，被广泛认为是导致不同结果的共同基础。为探讨中国汉族人群中人类白细胞抗原(HLADQB1)等位基因多态性与乙肝病毒感染结局的关系，对北京地区134例无症状乙肝病毒携带者和139例慢性乙型肝炎患者进行病例对照研究，采用序列特异性引物-聚合酶链式反应检测HLADQB1基因的13个等位基因。用SAS 9.1.2软件对两组的等位基因频率分布进行统计分析。调整混杂因素后，慢性乙肝组HLADQB10503、0303等位基因频率显著低于无症状携带者组(P=0.04；P=0.004)，饮酒频率明显高于无症状携带组(P=0.05)。HLADQB10503等位基因和0303等位基因是慢性乙型肝炎的独立抗性遗传因素，饮酒是慢性乙型病毒性肝炎的危险因素。
Host genetic factors and environment factors including hepatitis B virus (HBV) genotype are widely viewed as common basis of the different outcomes of HBV infection. Human leucocyte antigen (HLA) plays an important role in immunological reaction to HBV infection.The study aimed to explore whether the HLA-DQB1 allele polymorphisms are associated with the outcomes of HBV infection in the Chinese Han population.One hundred and thirty-four asymptomatic HBV carriers and 139 chronic hepatitis B patients were recruited in this case-control study in Beijing, China.Sequence-specific primers-polymerase chain reaction was used to detect 13 alleles of HLA-DQB1 gene. The frequency distributions of alleles in two groups were analysed using SAS 9.1.2 software. After adjustment of confounders the frequencies of HLA-DQB1*0503 allele and *0303 allele in chronic hepatitis B group were statistically significant lower than those in asymptomatic HBV carrier group (P = 0.04; P = 0.05), and the frequency of exposure to alcohol consumption in patients with chronic hepatitis B was clearly higher than that in asymptomatic HBV carrier group (P = 0.004).HLA-DQB1*0503 allele and *0303 allele are independently resistant genetic factors to chronic hepatitis B, and alcohol consumption is the risk factor of chronic hepatitis B.