The effect of butorphanol on the incidence of dexmedetomidine-induced emesis in cats
The effect of butorphanol on the incidence of dexmedetomidine-induced emesis in cats
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DOI：
10.1111/vaa.12260
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发表时间：
2015-11-01
影响因子：
1.7
通讯作者：
Kostoulas, Polychronis
中科院分区：
文献类型：
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作者：
Papastefanou, Anastasia K.;Galatos, Apostolos D.;Kostoulas, Polychronis
为了评价布托啡诺（BUT）与右美托咪啶（DEX）联合给药时对猫的止吐效果，研究设计双盲、随机对照交叉实验研究动物14只专门饲养的健康家猫，7只雌性和7只雄性，年龄中位数（范围）14-84（78）个月，体重1.7-5.5方法每只猫肌肉注射（IM）5种不同的治疗方案：（A）25 g kg（-1）DEX，（B）20 g kg（-1）DEX +0.2 mg kg（-1）BUT，（B）20 g kg（-1）BUT，（C）20 g kg（-1）BUT。（C）20gkg（-1）DEX和0.1mgkg（-1）BUT;（D）25gkg（-1）DEX和0.2mgkg（-1）BUT;和（E）20gkg（-1）DEX。在给药后8 min内记录呕吐的发生率、恶心的发生率和严重程度以及侧卧时间，并在此期间结束时对镇静进行评分。Friedman检验和Cochran's Q检验用于分析数据。显着性进行了评价，在5% level.ResultsThe呕吐的猫的比例显着降低与治疗方案，包括BUT（B，C和D）相比，仅包括DEX（A和E）的协议。与方案B和D相比，仅包括DEX的方案（A和E）中发生恶心的猫比例显著更高。治疗方案之间的侧卧时间（p=0.09）和镇静评分（p=0.07）无统计学差异。结论和临床意义布托啡诺可用于预防猫的呕吐和减少DEX引起的恶心的发生率和严重程度。BUT和DEX的组合似乎不仅在呕吐可能导致严重并发症时非常有用，而且还可以为轻微手术的镇静猫提供舒适和福祉。
Objectiveo evaluate the antiemetic effect of butorphanol (BUT) when co-administered with dexmedetomidine (DEX) in cats.Study designDouble-blind, randomized controlled cross-over experimental study.AnimalsFourteen purpose-bred healthy Domestic Short Hair cats, seven females and seven males, aged median (range) 14-84 (78)months and weighing 1.7-5.5 (4.0) kg.Methods Each cat received five different treatment protocols intramuscularly (IM): (A) 25gkg(-1) DEX; (B) 20gkg(-1) DEX and 0.2mgkg(-1) BUT; (C) 20gkg(-1) DEX and 0.1mgkg(-1) BUT; (D) 25gkg(-1) DEX and 0.2mgkg(-1) BUT; and (E) 20gkg(-1) DEX. Episodes of emesis, incidence and severity of nausea, and time to lateral recumbency were recorded for a period of 8minutes after treatment administration, and the sedation was scored at the end of this period. The Friedman test and the Cochran's Q-test were used to analyse the data. Significance was evaluated at the 5% level.ResultsThe proportion of cats that vomited was significantly lower with the treatment protocols that included BUT (B, C and D) compared with the protocols that included only DEX (A and E). The proportion of cats that had nausea was significantly higher with the protocols that included only DEX (A and E) compared with protocols B and D. Time to lateral recumbency (p=0.09) and sedation score (p=0.07) was not statistically different between the treatment protocols.Conclusions and clinical relevanceButorphanol can be used to prevent emesis and reduce the incidence and the severity of nausea caused by DEX in cats. It seems that the combination of BUT and DEX is very useful not only when emesis could result in serious complications, but also to provide comfort and well-being in cats sedated for minor procedures.