Dietary intake of fatty acids and serum C-reactive protein in Japanese.
Dietary intake of fatty acids and serum C-reactive protein in Japanese.
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DOI：
10.2188/jea.17.86
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发表时间：
2007-05
影响因子：
4.7
通讯作者：
Nakagawa H
中科院分区：
文献类型：
--
作者：
Yoneyama S;Miura K;Sasaki S;Yoshita K;Morikawa Y;Ishizaki M;Kido T;Naruse Y;Nakagawa H
炎症已被确定为心血管疾病的危险因素。多不饱和脂肪酸（PUFA）和单不饱和脂肪酸与炎症的关系在西方人群中仍有争议。日本人摄入的海产品中的长链n-3 PUFAs含量较高，两者之间的关系尚不清楚。我们对日本人群（1，556名男性和1，461名女性，年龄在35-60岁之间）进行了一项横断面流行病学研究。测定血清高敏C反应蛋白（CRP），并通过有效的自我管理的饮食史调查表评估7种特定脂肪酸的摄入量（能量%）。在调整混杂因素后，CRP与女性的油酸（p=0.008）和α -亚麻酸（p=0.026）摄入量呈显著负相关。多元回归分析显示，特别是在长链n-3 PUFA（二十碳五烯酸和二十二碳六烯酸）摄入量的中三分位数，CRP与男性和女性的油酸和亚油酸摄入量以及女性的α -亚麻酸摄入量呈负相关。油酸、亚油酸和α -亚麻酸的摄入会降低血清CRP，特别是当日本人摄入长链n-3 PUFA处于中等水平时。
Inflammation has been established as a risk factor for cardiovascular diseases. The relationships of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids to inflammation are still controversial in Western populations. The relationships are not clear in Japanese whose intake of seafood-based long-chain n-3 PUFAs is high. We conducted a cross-sectional epidemiologic study in the Japanese population (1,556 men and 1,461 women aged 35-60). Serum high sensitivity C-reactive protein (CRP) was measured, and intakes of 7 specific fatty acids (% of energy) were evaluated by a validated self-administered dietary history questionnaire. CRP was significantly and inversely related to the intakes of oleic acid (p=0.008) and α -linolenic acid (p=0.026) in women after adjustment for confounding factors. A multiple regression analysis showed that, especially in the middle tertile of long-chain n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) intake, CRP was inversely related to the intake of oleic acid and linoleic acid in both sexes and to the intake of α -linolenic acid in women. Intakes of oleic acid, linoleic acid, and α -linolenic acid would reduce serum CRP, especially when the intake of long-chain n-3 PUFAs is at a moderate level in Japanese.