Neuroendocrine Control of Sleep.
Neuroendocrine Control of Sleep.
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DOI：
10.1007/7854_2019_107
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发表时间：
2019
影响因子：
--
通讯作者：
Philip C. Smith;J. Mong
中科院分区：
文献类型：
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作者：
Philip C. Smith;J. Mong
睡眠是动物行为中的一种现象，它既神秘又无处不在，而且与内分泌功能密切相关。尽管关于睡眠及其功能的神经化学基础仍有许多未解之谜，但睡眠与内分泌系统之间广泛的相互作用已被确定，包括内分泌系统对睡眠的影响以及睡眠对内分泌系统的影响。不幸的是，直到最近几年，许多关于睡眠行为的研究在很大程度上忽视了它与内分泌系统的联系。因此，利用临床研究和啮齿动物模型来研究神经内分泌功能（包括生物性别）与睡眠之间的相互作用，是一个有前景的进一步探索领域。进一步研究睡眠的神经生物学和神经内分泌基础可能对许多临床和基础科学领域产生广泛的影响。在这篇综述中，我们总结了基本睡眠生物学的现状及其与神经内分泌生物学领域的联系，并提出了神经内分泌调节睡眠的未来关键方向，这可能会对女性和男性睡眠障碍的新疗法产生重大影响。
Sleep is a phenomenon in animal behavior as enigmatic as it is ubiquitous, and one deeply tied to endocrine function. Though there are still many unanswered questions about the neurochemical basis of sleep and its functions, extensive interactions have been identified between sleep and the endocrine system, in both the endocrine system’s effect on sleep and sleep’s effect on the endocrine system. Unfortunately, until recent years, much research on sleep behavior largely disregarded its connections with the endocrine system. Use of both clinical studies and rodent models to investigate interactions between neuroendocrine function, including biological sex, and sleep therefore presents a promising area of further exploration. Further investigation of the neurobiological and neuroendocrine basis of sleep could have wide impact on a number of clinical and basic science fields. In this review, we summarize the state of basic sleep biology and its connections to the field of neuroendocrine biology, as well as suggest key future directions for the neuroendocrine regulation of sleep that may significantly impact new therapies for sleep disorders in women and men.