Regional variation in brain white matter diffusion index changes following chemoradiotherapy: a prospective study using tract-based spatial statistics.
Regional variation in brain white matter diffusion index changes following chemoradiotherapy: a prospective study using tract-based spatial statistics.
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DOI：
10.1371/journal.pone.0057768
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Chapman CH;Nazem-Zadeh M;Lee OE;Schipper MJ;Tsien CI;Lawrence TS;Cao Y
人们对大脑白质结构对辐射的反应有何不同知之甚少，这可能对辐射引起的神经认知障碍产生影响。我们使用弥散张量成像（DTI）来检查放化疗后白质变化的区域变化。 14 名接受两周或三周全脑放射治疗 (RT) ± 化疗的患者在 RT 前、RT 结束时和 RT 后 1 个月接受了 DTI。测量了三个扩散指数：分数各向异性 (FA)、径向扩散率 (RD) 和轴向扩散率 (AD)。我们使用基于束的空间统计确定了扩散指数的显着个体体素变化，以及十四个感兴趣的白质结构内指数的平均变化。在所有结构中都观察到 FA 显着降低和 RD 显着增加的体素 (p<0.05)，其中穹窿、扣带回和胼胝体的变化最大 (20-50%)。 RT 前至 RT 结束时的平均 FA 变化存在高度显着的结构间差异 (p<0.001)。下扣带回从 RT 前到 RT 结束时的平均 FA 下降显着大于其他 13 个结构中的 11 个（p<0.00385）。通过 DTI 变化测量，大脑白质结构对放化疗的反应差异很大。与白质脱髓鞘相关的 FA 和 RD 变化在扣带回和穹窿中最为突出，这些结构与辐射引起的神经认知障碍有关。未来的研究应该评估 DTI 作为脑放化疗不良反应的预测生物标志物。
There is little known about how brain white matter structures differ in their response to radiation, which may have implications for radiation-induced neurocognitive impairment. We used diffusion tensor imaging (DTI) to examine regional variation in white matter changes following chemoradiotherapy. Fourteen patients receiving two or three weeks of whole-brain radiation therapy (RT) ± chemotherapy underwent DTI pre-RT, at end-RT, and one month post-RT. Three diffusion indices were measured: fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). We determined significant individual voxel changes of diffusion indices using tract-based spatial statistics, and mean changes of the indices within fourteen white matter structures of interest. Voxels of significant FA decreases and RD increases were seen in all structures (p<0.05), with the largest changes (20–50%) in the fornix, cingula, and corpus callosum. There were highly significant between-structure differences in pre-RT to end-RT mean FA changes (p<0.001). The inferior cingula had a mean FA decrease from pre-RT to end-RT significantly greater than 11 of the 13 other structures (p<0.00385). Brain white matter structures varied greatly in their response to chemoradiotherapy as measured by DTI changes. Changes in FA and RD related to white matter demyelination were prominent in the cingula and fornix, structures relevant to radiation-induced neurocognitive impairment. Future research should evaluate DTI as a predictive biomarker of brain chemoradiotherapy adverse effects.
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影响因子：
3.5
作者：
Cao, Yue
通讯作者：
Cao, Yue
DOI：
10.1111/j.1754-9485.2011.02282.x
发表时间：
2011-08-01
影响因子：
1.6
作者：
Marsh, James C.;Godbole, Rohit;Turian, Julius V.
通讯作者：
Turian, Julius V.
影响因子：
48
作者：
Douw, Linda;Klein, Martin;Heimans, Jan J.
通讯作者：
Heimans, Jan J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.4
作者：
Dellani, Paulo R.;Eder, Stefan;Gutjahr, Peter
通讯作者：
Gutjahr, Peter