Breastfeeding and risk of epithelial ovarian cancer
Breastfeeding and risk of epithelial ovarian cancer
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DOI：
10.1007/s10552-009-9440-x
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发表时间：
2010-01-01
影响因子：
2.3
通讯作者：
Webb, Penelope M.
中科院分区：
文献类型：
--
作者：
Jordan, Susan J.;Siskind, Victor;Webb, Penelope M.
几项研究发现，母乳喂养与卵巢癌的发生呈负相关，但存在不一致之处。与母乳喂养持续时间的关系尚不清楚，也不确定这种联系是否因卵巢癌的组织亚型而异。我们试图澄清这些问题。2001至2005年间，参加了一项基于澳大利亚全人群的上皮性卵巢癌病例对照研究的产妇(1,092例病例和1,288例对照)完成了生殖/生活方式问卷。用Logistic回归方法计算优势比和95%可信区间来研究母乳喂养与卵巢癌的关系，发现总的母乳喂养时间(所有病程加在一起)与卵巢癌的发生呈强烈的负相关(OR=0.986，95%CI为0.978~0.994/月)，且与胎次无关。然而，超过12个月的个别哺乳期并没有带来明显的额外益处。母乳喂养与组织学亚型的关系似乎有所不同，因此我们没有看到母乳喂养持续时间与交界性浆液性癌或粘液性癌之间的关系，但与其他亚型之间的关系相反，尽管这些关系并不总是在统计学上显著。总母乳喂养时间较长似乎与卵巢癌总体风险的大幅降低有关，与分娩风险的降低无关，但这可能因组织学亚型而异。
Several studies have found inverse associations between breastfeeding and ovarian cancer occurrence but there are inconsistencies. The relationship with breastfeeding duration is unclear, and it is uncertain whether the association varies according to histological subtype of ovarian cancer. We sought to clarify these issues.Parous women who participated in an Australia-wide population-based case-control study of epithelial ovarian cancer between 2001 and 2005 (1,092 cases and 1,288 controls) completed a reproductive/lifestyle questionnaire. Logistic regression was used to calculate odds ratios and 95% confidence intervals to investigate relations between breastfeeding and ovarian cancer.We found a strong inverse association between total duration of breastfeeding (all episodes combined) and ovarian cancer occurrence (OR = 0.986, 95% CI 0.978-0.994 per month of breastfeeding) that appeared to be independent of parity. However, individual episodes of lactation beyond 12 months conferred no appreciable additional benefit. The relation with breastfeeding appeared to vary by histological subtype such that we saw no association between duration of breastfeeding and borderline serous cancers or mucinous cancers, but inverse associations for the other subtypes, although these were not always statistically significant.A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype.