Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a Geriatric Evaluation and Rehabilitation Unit
Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a Geriatric Evaluation and Rehabilitation Unit
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DOI：
10.1016/0167-4943(96)00709-1
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发表时间：
1996-07-01
影响因子：
4
通讯作者：
Trabucchi, M
中科院分区：
文献类型：
--
作者：
Bertozzi, B;Barbisoni, P;Trabucchi, M
在老年评估和康复中心（GERU），对连续入院的258名在简易精神状态检查（MMSE）中得分22分或以上的老年患者（男：71，女：187；平均年龄77.4+/-7.5）进行评估，以评估非甾体抗炎药（NSAID）长期治疗对非痴呆老年患者认知状态的影响。 66 名患者 (25.6%) 被认为是长期 NSAID 使用者。长期服用 NSAID 的患者的 MMSE 评分显着高于非使用者（26.9 +/- 2.1 vs. 25.7 +/- 2.5，P < 0.0005）。在控制多变量模型中的潜在混杂因素后，长期使用 NSAID 仍与 MMSE 评分独立相关。结果支持非痴呆老年患者的长期 Nh;AID 使用与认知功能之间呈正相关。需要随机对照试验来明确证明这种有益效果。
In a geriatric evaluation and rehabilitation unit (GERU), 258 elderly patients (M: 71, F: 187; mean age 77.4 +/- 7.5) scoring 22 or more at Mini-Mental State Examination (MMSE) consecutively admitted were assessed in order to evaluate the effects of non-steroidal anti-inflammatory drugs (NSAID) chronic treatment on cognitive status in non-demented elderly patients. Sixty-six patients (25.6%) were considered chronic NSAID users. Patients chronically assuming NSAIDs showed a significantly higher MMSE score than non-users (26.9 +/- 2.1 vs. 25.7 +/- 2.5, P < 0.0005). After controlling for potential confounders in a multivariate model, chronic NSAID use remained independently associated with MMSE score. The results support a positive association between chronic Nh;AID use and cognitive function in non-demented elderly patients. Randomized controlled trials will be needed to definitively prove this beneficial effect.