HIPPOCAMPAL ATROPHY IN NORMAL AGING - AN ASSOCIATION WITH RECENT MEMORY IMPAIRMENT
HIPPOCAMPAL ATROPHY IN NORMAL AGING - AN ASSOCIATION WITH RECENT MEMORY IMPAIRMENT
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DOI：
10.1001/archneur.1993.00540090066012
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发表时间：
1993-09-01
影响因子：
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通讯作者：
FERRIS, SH
中科院分区：
文献类型：
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作者：
GOLOMB, J;DELEON, MJ;FERRIS, SH
目的.-估计正常衰老样本中放射线可检测到的海马萎缩 (HA) 的患病率，并测试这种萎缩是否与记忆功能障碍有关。设计.-154 名身体健康且认知正常的老年人（55 至 88 岁）接受了旨在识别 HA 的磁共振成像和/或计算机断层扫描。其中一百四十五名受试者还接受了记忆功能的心理测试。使用多变量方差分析来评估有和没有 HA 的受试者之间记忆表现的差异。-这项研究是在一家研究诊所进行的，目的是调查与年龄相关的神经心理学和神经放射学变化。参与者-根据以下标准，从参与正常衰老研究的较大老年研究志愿者组中连续选择 154 名受试者：年龄 55 岁或以上；整体恶化量表得分为 2 或更低；简易精神状态检查分数为 28 或更高。有重大医学、精神或神经系统疾病证据的受试者被排除在外。 主要结果测量。-结果测量包括个人心理测试分数和计算机断层扫描-磁共振成像海马萎缩评级。结果。-近 33% 的受试者有 HA 的放射学证据。 HA 的患病率随着年龄的增长而显着增加，男性比女性更常见。在控制年龄、教育水平和词汇量后，发现与没有 HA 的受试者相比，有 HA 的受试者在近期（二级）言语记忆测试中表现更差（P
Objective.-To estimate the prevalence of radiographically detectable hippocampal atrophy (HA) in a normal aging sample and to test whether such atrophy is associated with memory dysfunction.Design.-One hundred fifty-four medically healthy and cognitively normal elderly persons (aged 55 to 88 years) received magnetic resonance imaging and/or computed tomographic scans designed to identify HA. One hundred forty-five of these subjects also underwent psychometric tests of memory function. Multivariate analyses of variance were used to evaluate differences in memory performance between subjects with and without HA.Setting.-This study was conducted at a research clinic for the investigation of age-associated neuropsychological and neuroradiologic changes.Participants-Based on the following criteria, 154 subjects were consecutively selected from a larger group of elderly research volunteers participating in a study of normal aging: age of 55 years or greater; Global Deterioration Scale score of 2 or less; and Mini-Mental State examination score of 28 or greater. Subjects with evidence for significant medical, psychiatric, or neurologic disease were excluded.Main Outcome Measure.-Outcome measurements included individual psychometric test scores and computed tomographic-magnetic resonance imaging hippocampal atrophy ratings.Results.-Nearly 33% of the subjects had radiographic evidence for HA. The prevalence of HA increased significantly with age and was more common in male than female subjects. After controlling for age, level of education, and vocabulary, subjects with HA were found to perform more poorly on tests of recent (secondary) verbal memory when compared with subjects without HA (P