Pulmonary relapse of non-Hodgkin's lymphoma in bilateral upper lobes
Pulmonary relapse of non-Hodgkin's lymphoma in bilateral upper lobes
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DOI：
10.2169/internalmedicine.45.1636
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发表时间：
2006-01-01
影响因子：
1.2
通讯作者：
Taniwaki, Masafumi
中科院分区：
文献类型：
--
作者：
Fujimoto, Yoshiko;Nomura, Kenichi;Taniwaki, Masafumi
我们报告一位68岁男性弥漫性大B细胞淋巴瘤(DLBCL)患者，双侧肺上叶复发。病人出现咳嗽、虚弱和发烧的症状。胸部X线片显示双侧肺上叶有一支气管血管淋巴管炎样阴影。虽然细胞学和细胞荧光检查显示在支气管肺泡灌洗液中没有发现恶性细胞，但经支气管肺活检(TBLB)显示DLBCL累及支气管粘膜。复发性淋巴瘤倾向于沿着支气管血管束扩展，导致肉芽肿实变，可能类似于结核病，很可能累及下叶。因此，对非霍奇金淋巴瘤(NHL)肺部受累的诊断，Tblb是必不可少的。
We describe a 68-year-old male patient with diffuse large B-cell lymphoma (DLBCL) who suffered from relapse in bilateral upper lobes of the lung. The patient presented with cough, weakness and fever. A bronchovascular-lymphangitis-like shadow was detected in the bilateral upper lobes on a chest roentgenogram. Although cytological and cytofluorometric examinations revealed no malignant cells in the bronchoalveolar lavage fluid, trans-bronchial lung biopsy (TBLB) showed involvement of DLBCL in the bronchial mucosa. Recurrent lymphoma tends to extend along the bronchovascular bundles, resulting in granulomatous consolidation that may mimic tuberculosis and is likely to involve the lower lobes. Thus, TBLB proved to be essential for the diagnosis of the lung involvement of non-Hodgkin's lymphoma (NHL).