Decoding the Neuroanatomical Basis of Reading Ability: A Multivoxel Morphometric Study
Decoding the Neuroanatomical Basis of Reading Ability: A Multivoxel Morphometric Study
复制标题
解码阅读能力的神经解剖学基础：多体素形态测量研究
DOI：
10.1523/jneurosci.0449-13.2013
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发表时间：
2013-07-31
影响因子：
5.3
通讯作者：
Dong, Qi
中科院分区：
文献类型：
--
作者：
He, Qinghua;Xue, Gui;Dong, Qi
阅读作为人类进化过程中一项相对较新的文化发明，是个人发展和社会经济成功的重要途径。尽管阅读能力的个体差异得到了很好的证明，但其神经解剖学相关性尚未得到很好的理解，这主要是因为阅读是一种由多个组成部分组成的复杂技能。本研究以416名大学生为被试，采用7个阅读任务，成功地识别出了阅读能力的三个不相关的成分：语音解码、形音联想和命名速度。然后，我们试图预测个人的分数在这些组件从他们的灰质体积（GMV）的参与者的子集（N = 253）与高质量的结构图像，采用多元支持向量回归分析与十倍交叉验证。我们的研究结果揭示了支持阅读能力的不同方面的不同神经区域：而语音解码与GMV在左上级顶叶延伸到缘上回，形-音协会预测的GMV在海马和小脑。在枕叶、颞叶、顶叶和额叶皮层的分布脑区，运动速度与GMV相关。语音解码和形音联想与一般认知能力无关。然而，命名速度与智力和处理速度相关，一些预测命名速度的区域也预测了这些一般的认知能力。这些结果为进一步理解阅读的认知和神经结构以及阅读能力个体差异的结构基础提供了依据。
As a relatively recent cultural invention in human evolution, reading is an important gateway to personal development and socioeconomic success. Despite the well documented individual differences in reading ability, its neuroanatomical correlates have not been well understood, largely due to the fact that reading is a complex skill that consists of multiple components. Using a large sample of 416 college students and 7 reading tasks, the present study successfully identified three uncorrelated components of reading ability: phonological decoding, form-sound association, and naming speed. We then tried to predict individuals' scores in these components from their gray matter volume (GMV) on a subset of participants (N = 253) with high-quality structural images, adopting a multivariate support vector regression analysis with tenfold cross-validation. Our results revealed distinct neural regions that supported different aspects of reading ability: whereas phonological decoding was associated with the GMV in the left superior parietal lobe extending to the supramarginal gyrus, form-sound association was predicted by the GMV in the hippocampus and cerebellum. Naming speed was associated with GMV in distributed brain regions in the occipital, temporal, parietal, and frontal cortices. Phonological decoding and form-sound association were uncorrelated with general cognitive abilities. However, naming speed was correlated with intelligence and processing speed, and some of the regions that were predictive of naming speed also predicted these general cognitive abilities. These results provide further insights on the cognitive and neural architecture of reading and the structural basis of individual differences in reading abilities.