GRAFTS OF FETAL DOPAMINE NEURONS SURVIVE AND IMPROVE MOTOR FUNCTION IN PARKINSONS-DISEASE
GRAFTS OF FETAL DOPAMINE NEURONS SURVIVE AND IMPROVE MOTOR FUNCTION IN PARKINSONS-DISEASE
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DOI：
10.1126/science.2105529
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发表时间：
1990-02-02
期刊：
影响因子：
56.9
通讯作者：
BJORKLUND, A
中科院分区：
文献类型：
--
作者：
LINDVALL, O;BRUNDIN, P;BJORKLUND, A
神经移植可恢复帕金森病动物模型纹状体多巴胺能神经传递。现在已经证明，从胎龄8 - 9周的人类胎儿中获得的中脑多巴胺神经元可以在人类大脑中存活，并对严重患有特发性帕金森病的患者产生显著和持续的症状缓解。经6-L-[18F]氟多巴正电子发射断层扫描评估，通过立体定向手术将移植物单侧植入壳核，恢复了移植物区域多巴胺的合成和储存。这种神经化学变化伴随着患者的严重僵硬和运动迟缓在治疗上的显著减少，以及在最佳药物治疗期间患者病情波动的显著减少（“一次性”现象）。移植侧的临床改善最为显著。
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson''s disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson''s disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient''s severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient''s condition during optimum medication (the "one-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.