Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development
Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development
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DOI：
10.1016/j.neuroimage.2008.02.023
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Khong, Pek-Lan
中科院分区：
文献类型：
--
作者：
Qiu, Deqiang;Tan, Li-Hai;Khong, Pek-Lan
利用磁共振扩散张量成像（DTI）和先进的体素分析工具，研究了从儿童晚期到青年期白色物质的扩散率和各向异性变化，并将定量扩散指数与中文和英文阅读成绩进行了相关分析。招募了75名正常健康的在校中国学生和三个年龄组的年轻人（第1组，n = 24，平均+/- SD = 7.4 +/- 0.3岁;第2组，n = 27，平均+/- SD = 10.3 +/- 0.5岁;第3组，n = 24，平均+/- SD = 22.8 +/- 2.3岁）。DTI以3 mm各向同性分辨率进行，以覆盖整个大脑。使用基于道的空间统计（TBSS）进行逐体素分析，以定位白色物质区域，显示组间各向异性分数（FA）、平均扩散率（MD）以及轴向和径向扩散率的显著变化。我们发现，随着年龄的增长，小脑白色物质，右颞白色物质，以及大部分的上级额和顶叶白色物质的径向扩散率和轴向扩散率的降低与前者在更大程度上驱动的区域FA增加和MD减少。从儿童晚期到青年期，变化是持续的。通过特定白色物质束的感兴趣区域分析证实了结果。在控制了年龄的影响后，发现左内囊前肢的扩散指数与中文阅读评分（p = 0.05）、放射冠的扩散指数与英文阅读评分（左右侧分别为p = 0.026和p = 0.029）之间存在显著相关性。这些DTI指数可能反映了大脑发育过程中发生的多种生物学过程，这些过程为持续的功能连接（包括阅读发育）提供了神经基质。(c)2008年爱思唯尔公司All rights reserved.
Using diffusion tensor MR imaging (DTI) and advanced voxel-wise analysis tools, we study diffusivity and anisotropy changes of white matter from late childhood to young adulthood, and correlate quantitative diffusion indices with Chinese and English reading performance scores. Seventy-five normal healthy school going ethnic Chinese students and young adults of three age groups were recruited (group 1, n = 24, mean +/- SD = 7.4 +/- 0.3 years; group 2, n = 27, mean +/- SD = 10.3 +/- 0.5 years; group 3, n = 24, mean +/- SD = 22.8 +/- 2.3 years). DTI was performed with 3 mm isotropic resolution to cover the entire brain. Voxel-wise analysis was performed using Tract-Based Spatial Statistics (TBSS) to localize regions of white matter showing significant changes of fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities between groups. We found increased FA and decreased MD with increasing age in regions of cerebellar white matter, right temporal white matter, and a large portion of the superior frontal and parietal white matter driven by both the reduction of radial diffusivity and axial diffusivity with the former to a greater extent. Changes were continual from late childhood to young adulthood. Findings were confirmed by region-of-interest analysis in specific white matter tracts. After controlling for the effect of age, significant correlation was found between diffusion indices of the anterior limb of the left internal capsule and Chinese reading score (p = 0.05), and of the corona radiata and English reading score (p = 0.026 and p = 0.029 for left and right, respectively). These DTI indices likely reflect the multiple biological processes that occur during brain development which provide the neural substrate for ongoing functional connectivity including for reading development. (c) 2008 Elsevier Inc. All rights reserved.