Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed-head injury model
Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed-head injury model
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DOI：
10.1111/jnc.14673
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发表时间：
2019-06-01
影响因子：
4.7
通讯作者：
Fitzgerald, Melinda
中科院分区：
文献类型：
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作者：
Fehily, Brooke;Bartlett, Carole A.;Fitzgerald, Melinda
轻度创伤性脑损伤（mTBI）后，进一步的轻度影响可能会加剧负面后果。为了比较重复mTBI次数增加后的慢性损伤和缺陷，使用重复mTBI的闭头重量下降模型以24小时间隔向成年雌性大鼠递送1、2或3个mTBI。在首次mTBI后3个月评估结局。未发现明显运动、感觉或反射缺陷（p > 0.05），与当前文献一致。使用Morris水迷宫评估的认知功能显示，与假手术组相比，1和2次mTBI后出现慢性记忆缺陷，但3次mTBI后没有（p
Following mild traumatic brain injury (mTBI), further mild impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model of repeated mTBI was used to deliver 1, 2 or 3 mTBIs to adult female rats at 24 h intervals. Outcomes were assessed at 3 months following the first mTBI. No gross motor, sensory or reflex deficits were identified (p > 0.05), consistent with current literature. Cognitive function assessed using a Morris water maze revealed chronic memory deficits following 1 and 2, but not 3 mTBI compared to shams (p