Correlations in ion channel expression emerge from homeostatic tuning rules
Correlations in ion channel expression emerge from homeostatic tuning rules
复制标题
DOI：
10.1073/pnas.1309966110
复制
发表时间：
2013-07-09
影响因子：
11.1
通讯作者：
Marder, Eve
中科院分区：
文献类型：
--
作者：
O'Leary, Timothy;Williams, Alex H.;Marder, Eve
实验观察表明，不同离子通道的表达水平在定义类型的神经元之间变化，即使这些神经元表现出刻板的电特性。然而，不同的离子通道表达水平之间存在强相关性，尽管确定这些相关性的机制尚不清楚。使用通用模型神经元，我们表明，相关的电导表达可以出现从简单的稳态控制机制，耦合表达率的个人电导细胞读出的活动。相关性取决于不同电导的相对表达率。因此，可变性是一致的稳态调节和结构的这种可变性揭示了不同电导的调节动态之间的定量关系。此外，我们表明，稳态调节是非常不敏感的细节，耦合的一个给定的电导的调节，因为在多个电导的功能退化的整体神经元活动，可以是强大的“反稳态”调节的一个子集的电导在细胞中表达。
Experimental observations reveal that the expression levels of different ion channels vary across neurons of a defined type, even when these neurons exhibit stereotyped electrical properties. However, there are robust correlations between different ion channel expression levels, although the mechanisms that determine these correlations are unknown. Using generic model neurons, we show that correlated conductance expression can emerge from simple homeostatic control mechanisms that couple expression rates of individual conductances to cellular readouts of activity. The correlations depend on the relative rates of expression of different conductances. Thus, variability is consistent with homeostatic regulation and the structure of this variability reveals quantitative relations between regulation dynamics of different conductances. Furthermore, we show that homeostatic regulation is remarkably insensitive to the details that couple the regulation of a given conductance to overall neuronal activity because of degeneracy in the function of multiple conductances and can be robust to "antihomeostatic" regulation of a subset of conductances expressed in a cell.