Child care setting affects salivary cortisol and antibody secretion in young children.
Child care setting affects salivary cortisol and antibody secretion in young children.
复制标题
儿童保育环境会影响幼儿的唾液皮质醇和抗体分泌。
DOI：
10.1016/j.psyneuen.2010.02.001
复制
发表时间：
2010
影响因子：
3.7
通讯作者：
Robertson,StevenS
中科院分区：
文献类型：
--
作者：
Watamura,SarahEnos;Coe,ChristopherL;Laudenslager,MarkL;Robertson,StevenS
在儿童看护期间，下午皮质醇水平升高的现象一再出现。然而，目前尚不清楚这些升高是否会产生任何后果。由于生理应激系统和免疫系统在功能上是联系在一起的，我们研究了唾液皮质醇浓度和抗体分泌之间的关系，在一天中，在家里和儿童保育，以及它们与父母报告的疾病。唾液抗体提供了一个关键的防线，防止病原体通过口腔进入，但很少有人知道它的昼夜节律在幼儿或不同的环境背景的影响。唾液样本大约在上午10点30分采集，下午3：30和晚上8：00在两个儿童保育和两个家庭日在65个3-5岁的儿童参加非常高质量的，全职儿童保育中心的样本。结果表明：（1）在儿童护理中，下午水平较高导致皮质醇水平上升，预示着随后周末的抗体水平较低;（2）周末皮质醇水平较高与父母报告的疾病有关;（3）对于年龄较大的学龄前儿童，sIgA的每日下降模式在周末和儿童护理日明显，但对于年龄较小的学龄前儿童，仅在周末。结果表明，儿童在儿童保育期间皮质醇升高可能与抗体水平降低和疾病频率增加有关。
Elevated afternoon levels of cortisol have been found repeatedly in children during child care. However, it is unclear whether these elevations have any consequences. Because physiologic stress systems and the immune system are functionally linked, we examined the relationship between salivary cortisol concentration and antibody secretion across the day at home and in child care, and their relationships with parent-reported illnesses. Salivary antibody provides a critical line of defense against pathogens entering via the mouth, but little is known about its diurnal rhythm in young children or the effect of different environmental contexts. Saliva samples were taken at approximately 10:30 a.m., 3:30 p.m. and 8:00 p.m. on two child care and two home days in a sample of 65 3–5-year-old children attending very high quality, full time child care centers. Results indicated that (1) a rising cortisol profile at child care, driven by higher afternoon levels, predicted lower antibody levels on the subsequent weekend, (2) higher cortisol on weekend days was related to greater parent-reported illness, and (3) a declining daily pattern in sIgA was evident on weekend and child care days for older preschoolers, but only on weekend days for younger preschoolers. The results suggest that elevated cortisol in children during child care may be related to both lowered antibody levels and greater illness frequency.