Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer
Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer
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使用 8 MHz 射频电容装置进行深部区域热疗对癌症患者的心脏和呼吸系统影响
DOI：
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发表时间：
2017
影响因子：
3.1
通讯作者：
A. Chishaki
中科院分区：
文献类型：
--
作者：
Rieko Izukura;H. Imada;N. Hashiguchi;H. Sawatari;T. Ohguri;M. Miyazono;Shin Ohta;Chiduko Takakura;K. Yamasaki;Chie Magota;Kanae Fujita;H. Kuroda;Hideki Hirata;T. Ohkusa;A. Chishaki
摘要 目的：热疗（HT）作为多种癌症的辅助治疗，可能会引起患者的生理变化，从而导致心血管问题。在各种HT治疗中，深层局部HT的生理效应仍不清楚。我们检查了整个深部区域 HT 的生理变化，以提高 HT 的安全性。材料和方法：31 名癌症患者（年龄：61±12 岁）使用 8 MHz 射频电容装置在胸部或上腹部区域接受 HT 治疗 50 分钟。在整个 HT 过程中评估直肠温度 (Trec)、收缩压和舒张压（SBP 和 DBP）、脉率 (PR)、呼吸频率 (RR)、经皮血氧饱和度 (SpO2) 和出汗量。结果：开始 HT 50 分钟后，Trec、PR 和 RR 与基线值相比显着增加（Trec：38.2±±1.4 vs. 36.3±±0.8°C，p<±0.001，PR：104±±15 vs. 85±±16） bpm，p< 0.05，RR：23 ± 3 与 21 ± 3/分钟，p < 0.05）。尽管卧位期间 HT 期间的平均 SBP 和 DBP 均稳定，但站立位时这些值显着下降（SBP：113±±16 vs 127±±18 mmHg，p<±0.001；DBP：70±±12 vs 127±±18 mmHg）。 75 ± 13 mmHg，p < 0.01）。出汗总量平均为356±173g/m2。结论：深部区域 HT 增加了深部体温，导致出汗增加，周围血管舒张。因此，HT 后站立会导致血压显着降低。接受 HT 的患者需要特别注意，尤其是在 HT 后站立时。
Abstract Purpose: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. Materials and methods: Thirty-one patients (age: 61 ± 12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min. Rectal temperature (Trec), systolic and diastolic blood pressures (SBP and DBP), pulse rate (PR), respiratory rate (RR), percutaneous oxygen saturation (SpO2) and sweating volume were evaluated throughout HT. Results: At 50 min after starting HT, Trec, PR and RR were significantly increased compared with the baseline values (Trec: 38.2 ± 1.4 vs. 36.3 ± 0.8 °C, p < 0.001, PR: 104 ± 15 vs. 85 ± 16 bpm, p < 0.05, RR: 23 ± 3 vs. 21 ± 3/min, p < 0.05). Although the average SBP and DBP were both stable during HT in a recumbent position, these values dropped significantly in a standing position (SBP: 113 ± 16 vs. 127 ± 18 mmHg, p < 0.001, DBP: 70 ± 12 vs. 75 ± 13 mmHg, p < 0.01). The total amount of sweating was 356 ± 173 g/m2 on average. Conclusions: Deep regional HT increased the deep body temperature and resulted in an increase of sweating with peripheral vasodilatation. Consequently, a significant reduction in BP would be induced on standing after HT. Careful attention is needed for patients receiving HT, especially when standing after HT.
使用环形相控阵系统加热深部偏心肿瘤：使用两种环形阵列操作配置的比较临床研究。
DOI：
10.1016/0360-3016(87)90264-1
发表时间：
1987
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
Samulski,TV;Kapp,DS;Fessenden,P;Lohrbach,A
通讯作者：
Lohrbach,A
DOI：
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发表时间：
--
期刊：
Environmental Science and Pollution Research International
影响因子：
--
作者：
P. Wust;B. Hildebrandt;G. Sreenivasa;B. Rau;J. Gellermann;H. Riess;R. Felix;P. Schlag
通讯作者：
P. Wust;B. Hildebrandt;G. Sreenivasa;B. Rau;J. Gellermann;H. Riess;R. Felix;P. Schlag