Evolution of the immune system in humans from infancy to old age.
Evolution of the immune system in humans from infancy to old age.
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DOI：
10.1098/rspb.2014.3085
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发表时间：
2015-12-22
期刊：
影响因子：
--
通讯作者：
McMichael A
中科院分区：
文献类型：
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作者：
Simon AK;Hollander GA;McMichael A
本文综述了新生儿、婴儿和成年人（包括怀孕）免疫反应的发展，并以老年时的下降结束。一个孩子出生时就有一个不成熟的、先天的和适应性的免疫系统，随着他或她的成长，这个免疫系统会成熟并获得记忆。然后进入老年衰退。这些变化与不同类型的感染，自身免疫性疾病和恶性肿瘤的风险一起考虑。
This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.