Beliefs about causes of autism and vaccine hesitancy among parents of children with autism spectrum disorder
Beliefs about causes of autism and vaccine hesitancy among parents of children with autism spectrum disorder
复制标题
DOI：
10.1016/j.vaccine.2020.07.034
复制
发表时间：
2020-09-11
期刊：
影响因子：
5.5
通讯作者：
Boom, Julie A.
中科院分区：
文献类型：
--
作者：
Goin-Kochel, Robin P.;Fombonne, Eric;Boom, Julie A.
在自闭症谱系障碍（ASD）儿童的父母中，疫苗犹豫可能更为常见。我们研究了参与SPARK研究（Simons Foundation powered Autism Research for Knowledge）的ASD儿童照料者中与ASD特异性疫苗犹豫相关的因素。225名参与者完成了一项在线调查，其中包括父母对儿童疫苗的态度（PACV）问卷（疫苗犹豫的测量）和ASD儿童父母的疾病感知问卷（IPQ-R-ASD；父母对ASD的看法的测量）。65名参与者（28.8%）对疫苗犹豫（PACV评分为50分）；疫苗犹豫父母（VHPs）的孩子头胎出生的可能性更小（n = 27,41.5%），自闭症症状严重程度更高（社会沟通问卷平均得分= 23.9,SD = 6.9），更容易出现发育倒退（n = 27,50.9%）或平台期（n = 37,69.8%）。与不犹豫的父母相比，VHPs明显更多地认为事故/伤害、孩子免疫系统恶化、饮食、环境污染、一般压力、父母的负面观点、父母的行为/决定、父母的情绪状态和疫苗是导致ASD的原因。在IPQ-R的个人控制、治疗控制、疾病一致性和情绪表征分量表上，vhp的得分也高于非犹豫型父母。在最后的模型中，与ASD相关的疫苗犹豫与情绪表征子量表得分较高（OR = 1.13, p = 0.10）、儿童免疫力下降作为ASD的原因（OR = 12.47, p < 0.001）、儿童没有达到流利的语言（OR = 2.67, p = 0.17）和儿童经历发育平台（OR = 3.89, p = 0.002）显著相关。研究结果表明，儿童功能和发育历史以及父母对ASD的负面看法和控制感共同影响了ASD儿童父母对疫苗的犹豫。(C) 2020 Elsevier Ltd.版权所有。
Vaccine hesitancy may be more common among parents of children with autism spectrum disorder (ASD). We examined factors associated with ASD-specific vaccine hesitancy among caregivers of children with ASD who participated in the SPARK study (Simons Foundation Powering Autism Research for Knowledge). 225 participants completed an online survey containing the Parent Attitudes About Childhood Vaccines (PACV) questionnaire (measure of vaccine hesitancy) and the Illness Perception Questionnaire revised for parents of children with ASD (IPQ-R-ASD; measure of parents' views about ASD). 65 participants (28.8%) were vaccine hesitant (PACV score > 50); children of vaccine-hesitant parents (VHPs) were less likely to be first born (n = 27, 41.5%), had greater ASD-symptom severity (mean Social Communication Questionnaire score = 23.9, SD = 6.9), and were more likely to have experienced developmental regression (n = 27, 50.9%) or plateau (n = 37, 69.8%). Compared to non-hesitant parents, VHPs significantly more often endorsed accident/injury, deterioration of the child's immune system, diet, environmental pollution, general stress, parents' negative views, parents' behaviors/decisions, parents' emotional state, and vaccines as causes for ASD. VHPs also had higher scores on the Personal Control, Treatment Control, Illness Coherence, and Emotional Representations subscales of the IPQ-R than did non-hesitant parents. In the final model, ASD-related vaccine hesitancy was significantly associated with higher scores on the Emotional Representations subscale (OR = 1.13, p = 0.10), agreement with deterioration of the child's immunity as a cause of ASD (OR = 12.47, p < 0.001), the child not having achieved fluent speech (OR = 2.67, p = 0.17), and the child experiencing a developmental plateau (OR = 3.89, p = 0.002). Findings suggest that a combination of child functioning and developmental history, as well as parents' negative views about and their sense of control over ASD, influence vaccine hesitancy among parents of children with ASD. (C) 2020 Elsevier Ltd. All rights reserved.