Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream
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DOI：
10.1038/nn.3297
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发表时间：
2013-02-01
影响因子：
25
通讯作者：
Tole, Shubha
中科院分区：
文献类型：
--
作者：
Huilgol, Dhananjay;Udin, Susan;Tole, Shubha
副嗅球(AOB)是一种重要的嗅觉结构，参与调节社会行为。它接受来自犁鼻器的输入，并投射到杏仁复合体中的靶点。它的前部和后部成分(aAOB和pAOB)在处理生殖、防御和攻击行为时分别表现出分子、连接和功能上的分离。我们在小鼠的aAOB和pAOB的投射神经元的发育过程中观察到了二分现象。我们发现它们有不同的起源部位，并且它们的规范和迁移需要不同的调节分子。AAOB神经元在端脑吻侧局部出现，与嗅球主神经元相似。相反，pAOB神经元从间脑-端脑交界处的神经上皮起于尾部，它们从那里向吻部迁移到达目的地。这种不同寻常的起源和迁徙在非洲爪哇被保存下来，为这个系统在进化中的一个关键组成部分的起源提供了洞察。
The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functional segregation in processing reproductive and defensive and aggressive behaviors, respectively. We observed a dichotomy in the development of the projection neurons of the aAOB and pAOB in mice. We found that they had distinct sites of origin and that different regulatory molecules were required for their specification and migration. aAOB neurons arose locally in the rostral telencephalon, similar to main olfactory bulb neurons. In contrast, pAOB neurons arose caudally, from the neuroepithelium of the diencephalic-telencephalic boundary, from which they migrated rostrally to reach their destination. This unusual origin and migration is conserved in Xenopus, providing an insight into the origin of a key component of this system in evolution.