Circulating Soluble Intercellular Adhesion Molecule 1 and Subclinical Atherosclerosis: the Coronary Artery Risk Development in Young Adults Study
Circulating Soluble Intercellular Adhesion Molecule 1 and Subclinical Atherosclerosis: the Coronary Artery Risk Development in Young Adults Study
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DOI：
10.1373/clinchem.2011.168559
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发表时间：
2012-02-01
影响因子：
9.3
通讯作者：
Jacobs, David R., Jr.
中科院分区：
文献类型：
--
作者：
Gross, Myron D.;Bielinski, Suzette J.;Jacobs, David R., Jr.
背景：可溶性细胞间粘附分子1 （sICAM-1）与内皮功能障碍和临床心血管疾病有关。我们研究了亚临床动脉粥样硬化与sICAM-1浓度的关系。方法：在年轻人冠状动脉风险发展（CARDIA）研究（黑人和白人男性和女性，平均年龄40岁）的第15年检测sICAM-1浓度。我们评估了第20年冠状动脉钙化（CAC）的进展（n = 2378），以及第20年颈动脉狭窄（n = 2432）和内膜-中膜厚度（IMT）的进展（n = 2240）。结果：sICAM-1的中位数为145.9 μ g/L。在晚期动脉粥样硬化斑块（CAC或狭窄）亚组中，在年龄、种族、性别、诊所、吸烟、运动、体型、教育、血压、降压药、血脂和降胆固醇药物调整后的模型中，每SD sICAM-1 （44 μ g/L）的IMT高0.010 （95% CI 0.003-0.017 mm）。同样调整后，sICAM-1每SD的20年颈动脉狭窄发生率的比值比（OR）为1.12 (95% CI 1.01-1.25, P < 0.04)，而CAC进展发生率的比值比为1.16 （1.04-1.31,P < 0.01）。在sICAM-1分布的前20位，与CAC和颈动脉狭窄的相关性最强。结论：sICAM-1浓度可能是一种早期生物标志物，表明动脉粥样硬化伴动脉壁变化，以及冠状动脉和颈动脉中存在晚期斑块。这一发现适用于动脉粥样硬化总负担较低的人群，比临床心血管疾病发展早几十年。(C) 2011美国临床化学学会
BACKGROUND: Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration.METHODS: sICAM-1 concentration was assayed at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) Study (black and white men and women, average age 40 years). We assessed progression of coronary artery calcification (CAC) through year 20 (n = 2378), and both carotid artery stenosis (n = 2432) and intima-media thickness (IMT) at year 20 (n = 2240).RESULTS: Median sICAM-1 was 145.9 mu g/L. Among a subgroup with advanced atherosclerotic plaque (either CAC or stenosis), IMT was 0.010 (95% CI 0.003-0.017 mm) higher per SD of sICAM-1 (44 mu g/L) in a model adjusted for age, race, sex, clinic, smoking, exercise, body size, education, blood pressure, antihypertensive medication, plasma lipids, and cholesterol-lowering medication. With the same adjustment, the odds ratio (OR) for the presence of year-20 carotid artery stenosis per SD of sICAM-1 was 1.12 (95% CI 1.01-1.25, P < 0.04), whereas for occurrence of CAC progression the OR was 1.16 (1.04-1.31, P < 0.01). The associations with CAC and carotid stenosis were strongest in the top 20th of the sICAM-1 distribution.CONCLUSIONS: sICAM-1 concentration may be an early biomarker that indicates changes in the artery wall that accompany atherosclerosis, as well as the presence of advanced plaque in the coronary and carotid arteries. This finding holds in people with low total burden of atherosclerosis, decades before the development of clinical CVD. (C) 2011 American Association for Clinical Chemistry