Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease.
Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease.
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DOI：
10.3389/fimmu.2024.1332776
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发表时间：
2024
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然炎症在许多神经系统疾病的发病机制中的理解现已被接受，但本专题评论阐述了在与炎症相关的认知雾、虚弱和抑郁的传播过程中研究慢性炎症的必要性，我们将其称为脑衰退综合征。脑衰退综合征患者处于神经学和精神病学之间的空白，因为在这些患者中看到的抑郁、疲劳和雾不是特发性的，而是由于参与神经系统疾病启动的器质性炎症。对中风、多发性硬化症、帕金森氏病、COVID、创伤性脑损伤和阿尔茨海默病的随机临床试验的回顾表明，将脑衰退综合征的任何组成部分作为主要终点的研究很少。此外，尽管相对广泛地接受炎症是这些疾病病理中的关键驱动因素的概念，但没有人将慢性炎症与抑郁、疲劳或雾联系起来，尽管超过一半的患者患有这些疾病。脑衰退综合征在我们检查的神经系统疾病中是重要和普遍的。经典的“精神药物”不足以解决脑衰退综合征，应该研究一种利用先天免疫反应和获得性免疫反应的顺序靶向的新方法。脑衰退综合症。从疾病的发病机制到找到正确的医生类型来处理脑衰退综合征，图解了患者面临的问题。
While the understanding of inflammation in the pathogenesis of many neurological diseases is now accepted, this special commentary addresses the need to study chronic inflammation in the propagation of cognitive Fog, Asthenia, and Depression Related to Inflammation which we name Brain FADE syndrome. Patients with Brain FADE syndrome fall in the void between neurology and psychiatry because the depression, fatigue, and fog seen in these patients are not idiopathic, but instead due to organic, inflammation involved in neurological disease initiation. A review of randomized clinical trials in stroke, multiple sclerosis, Parkinson’s disease, COVID, traumatic brain injury, and Alzheimer’s disease reveal a paucity of studies with any component of Brain FADE syndrome as a primary endpoint. Furthermore, despite the relatively well-accepted notion that inflammation is a critical driving factor in these disease pathologies, none have connected chronic inflammation to depression, fatigue, or fog despite over half of the patients suffering from them. Brain FADE Syndrome is important and prevalent in the neurological diseases we examined. Classical “psychiatric medications” are insufficient to address Brain FADE Syndrome and a novel approach that utilizes sequential targeting of innate and adaptive immune responses should be studied. Brain FADE Syndrome. Pictorial representation of the issues that patients face from disease pathogenesis to finding the correct type of physician to deal with Brain FADE Syndrome.
影响因子：
13.8
作者：
Golier, Julia A.;Li, Xue;Bizien, Marcel;Hurley, Robin A.;Bechard, Brendan W.;Kimbrell, Timothy;Flory, Janine D.;Baker, Dewleen G.;Yehuda, Rachel;Reda, Domenic J.
通讯作者：
Reda, Domenic J.