The evolving story of orexin biology: the hits keep coming.
The evolving story of orexin biology: the hits keep coming.
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DOI：
10.3410/b1-85
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Samson WK
中科院分区：
文献类型：
--
作者：
Samson WK
在发现后的短短11年内，食欲素（下丘脑分泌素）的研究不仅提供了对睡眠/觉醒生物学的深入了解，而且还证明了开发新的药理学工具和遗传模型的重要性，这些工具和模型可以理解基本的生理机制，并为治疗人类疾病提供潜在的策略。这里回顾了最近发表的新方法和发现的亮点。
In the span of just 11 years since their discovery, the study of the orexins (hypocretins) has not only provided insight into the biology of sleep/wakefulness, but also demonstrated the importance of the development of new pharmacologic tools and genetic models with which to understand basic physiologic mechanisms and provide potential strategies for the treatment of human pathologies. Highlights from recently published novel approaches and findings are reviewed here.