BONE MASS IN FEMALE CYNOMOLGUS MACAQUES - A CROSS-SECTIONAL AND LONGITUDINAL-STUDY BY AGE
BONE MASS IN FEMALE CYNOMOLGUS MACAQUES - A CROSS-SECTIONAL AND LONGITUDINAL-STUDY BY AGE
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DOI：
10.1007/bf00301684
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发表时间：
1994-03-01
影响因子：
4.2
通讯作者：
WEAVER, DS
中科院分区：
文献类型：
--
作者：
JAYO, MJ;JEROME, CP;WEAVER, DS
一项按年龄划分的横断面研究旨在评估和描述雌性食蟹猴（Macaca fasciculis）群体的骨矿物质含量（BMC，g）和密度（BMD，g/cm(2)）。采用双能X射线骨密度仪对171只年龄在3.7～22.0岁的雌性猴进行腰椎L2-L4节段的BMC(BMC(S))、BMD(BMD(S))、长度和全身BMC(BMC(TB))测量。将动物分为三个年龄组：（1）年轻组（< 6.5 岁，n = 51）； (2) 成人（> 6.5 岁且< 10.5 岁，n = 63）； (3) 成熟（> 10.5 岁，n = 57）。幼龄动物的体重显着低于成年动物（P < 0.05），躯干长度也较短。幼年动物的 BMC(S)、BMD(S) 和 BMC(TB) 也显着低于成年或成熟动物 (P < 0.05)，并且腰椎椎段显着短于 (P < 0.01) 其他两组。纵向上，63 只动物重复进行了腰椎扫描，以检查随时间的变化。随着时间的推移，幼龄动物的 BMC(S) 和 BMD(S) 表现出积极且显着的变化 (P < 0.05)，而成年动物的这些参数没有变化，而成熟动物则随着时间的推移有骨质流失的趋势。密度测量结果表明，腰椎骨量在 9 岁时达到峰值。制定了放射线照相和牙科标准来识别已达到峰值骨量的动物，并且组合放射线照相和牙科评分系统可靠地识别了动物 9 年和顺序。建议使用 9 岁或以上的雌性食蟹猴来研究骨重塑和相关疾病，例如骨质疏松症。
A cross-sectional study by age was designed to evaluate and describe the bone mineral content (BMC, g) and density (BMD, g/cm(2)) in a population of female cynomolgus macaques (Macaca fascicularis). Dual-energy X-ray absorptiometry was used to measure, in segments L2-L4 of the lumbar spine, the BMC (BMC(S)), BMD (BMD(S)), length, and total-body BMC (BMC(TB)) in 171 female monkeys ranging in age between 3.7 and 22.0 years. The animals were divided into three age groups: (1) young (< 6.5 years, n = 51); (2) adult (> 6.5 years and < 10.5 years, n = 63); and (3) mature (> 10.5 years, n = 57). Young animals had a significantly lower (P < 0.05) body weight and shorter trunk length than adult or mature animals. Young animals also had significantly less (P < 0.05) BMC(S), BMD(S), and BMC(TB), than adult or mature animals, and had significantly shorter (P < 0.01) lumbar spine vertebral segments than the other two groups. Longitudinally, 63 animals had repeated lumbar spine scans to examine changes over time. Young animals showed a positive and significant change (P < 0.05) in BMC(S) and BMD(S) through time, whereas these parameters did not change in adult animals, and mature animals had a trend towards bone loss through time. Densitometric results suggested that peak bone mass in the lumbar spine was achieved by 9 years of age. Radiographic and dental criteria were developed to identify animals that had reached peak bone mass, and the combined radiographic and dental scoring system reliably identified animals 9 years and order. Female cynomolgus macaques 9 years old or older are recommended for investigations of bone remodeling and associated conditions, such as osteoporosis.