Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function
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DOI：
10.1016/j.atherosclerosis.2010.05.011
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发表时间：
2010-09-01
期刊：
影响因子：
5.3
通讯作者：
Matsumoto, Toshio
中科院分区：
文献类型：
--
作者：
Yoshida, Sumiko;Aihara, Ken-ichi;Matsumoto, Toshio
背景：硫酸脱氢表雄酮（DHEAS）被认为与预期寿命和抗衰老有关。然而，其在动脉粥样硬化中的生物学意义仍有争议。因此，本研究的目的是确定DHEAS是否与具有心血管危险因素的受试者的颈动脉粥样硬化的发展有关。对象和方法：从日本德岛大学医院招募了419名日本人（男性208人，女性211人）。超声测量所有受试者颈动脉最大内膜厚度（max-IMT）、颈总动脉平均厚度（mean- imt）和平均血流量（mean blood flow volume， BFV）；通过肱动脉血流介导的血管舒张（%FMD）评估内皮功能。血清DHEAS和经典心血管危险因素也进行了评估。通过多元回归分析确定max-IMT、mean- imt、mean CCA-BFV和%FMD的独立决定因素，并确定统计学意义。结果：男性血清DHEAS水平高于女性。多元回归分析显示，DHEAS是男性max-IMT和mean-IMT的独立负向因子，而非女性。相比之下，DHEAS是女性平均CCA-BFV的唯一阳性因素，而不是男性。此外，无论性别和其他混杂因素，%FMD与DHEAS之间没有显著关系。结论：尽管DHEAS不参与内皮功能，但DHEAS与性别依赖性颈动脉粥样硬化呈负相关，如男性max-IMT和均值imt升高，女性CCA-BFV降低。2010爱思唯尔爱尔兰有限公司版权所有。
Background : Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. However, its biological significance in atherosclerosis remains controversial. Therefore, the aim of this study was to determine whether DHEAS is associated with development of carotid atherosclerosis in subjects with cardiovascular risk factors.Subjects and methods : A total of 419 Japanese individuals (208 males and 211 females) were recruited from Tokushima University Hospital, Japan. In all subjects, maximum intimamedia thickness (max-IMT) in all carotid arteries, and mean-IMT and mean blood flow volume (BFV) in the common carotid arteries (CCA) were measured by ultrasonography; endothelial function was assessed by flow-mediated vasodilation of the brachial artery (%FMD). Serum DHEAS and classical cardiovascular risk factors were also evaluated. Statistical significance was determined by multiple regression analysis to elucidate independent determinants of max-IMT, mean-IMT, mean CCA-BFV, and %FMD.Results : Serum DHEAS levels were higher in males than in females. Multiple regression analysis revealed that DHEAS was an independent negative factor for both max-IMT and mean-IMT in males but not in females. In contrast, DHEAS was the sole positive factor for mean CCA-BFV in females but not in males. In addition, there was no significant relationship between %FMD and DHEAS regardless of sex and other confounding factors.Conclusion : Although DHEAS is not involved in endothelial function, DHEAS is inversely associated with sex-dependent diverse carotid atherosclerosis such as increased max-IMT and mean-IMT in males and decreased CCA-BFV in females. (C) 2010 Elsevier Ireland Ltd. All rights reserved.