Determination of the environmentally safe threshold value of chloroacetophenone in waters
Determination of the environmentally safe threshold value of chloroacetophenone in waters
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发表时间：
2008
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通讯作者：
Z. Ruihua
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作者：
Z. Ruihua
本文介绍了氯苯乙酮对大鼠和家兔的毒理学研究结果，对大鼠的最低可见不良作用水平（LOAEL）和无可见不良作用水平（NOAEL）分别为2.032mg·kg-1和0.812mg·kg-1。介质有效浓度（96 h EC 50）L-1。因此，氯苯乙酮在沃茨中的环境安全阈值为0.36μg·L-1。根据实验结果的要求，EPA为保护人类健康而制定的环境水质标准的方法，以及欧盟关于风险评估的技术指导文件。
Toxicological studies of chloroacetophenone on rats and alga are presented and discussed.The lowest observed adverse effect level(LOAEL)and no observed adverse effect level(NOAEL)for rats were 2.032 mg·kg-1 and 0.812 mg·kg-1,respectively.The medium effective concentration(96 h EC50)for alga(scenedesmus obliquus)was 0.360 mg·L-1.The environmentally safe threshold value of chloroacetophenone in waters is therefore 0.36μg·L-1,as required by the experimental results,EPA's methodology for deriving ambient water quality criteria for the protection of human health,and the EU's technical guidance document on risk assessment.