Adiposity and Asthma in a Nationwide Study of Children and Adults in the United States
Adiposity and Asthma in a Nationwide Study of Children and Adults in the United States
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DOI：
10.1513/annalsats.201709-723oc
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发表时间：
2018-03-01
影响因子：
8.3
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
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作者：
Forno, Erick;Han, Yueh-Ying;Celedon, Juan C.
理由：虽然肥胖与哮喘相关，但体重指数不足以全面表征肥胖。目标：我们使用双能 X 射线吸收测定法定义的指数，检查了美国人口大样本中肥胖与哮喘之间的关系。方法：我们分析了 8,886 名儿童（8-19 岁）和 12,795 名成人（20-69 岁）的数据年）来自 2001 年至 2006 年全国健康和营养检查调查。除体重指数、体脂率、腰围、腰高比外，还采用双能X线骨密度仪计算全身和局部肥胖指数：脂肪质量指数；总脂肪、躯干脂肪和腿部脂肪百分比；躯干与总脂肪质量比、腿部与总脂肪质量比以及躯干与腿部脂肪质量比。使用逻辑回归分析肥胖指标和哮喘。结果：在儿童中，一般肥胖与哮喘显着相关，但性别之间没有显着差异。结果是由非过敏性儿童得出的，在这些儿童中，躯干为主的（中央）肥胖（通过腰围、腰高比、躯干与总脂肪质量比以及躯干与腿部脂肪质量比进行评估）也与哮喘相关。特应性儿童之间没有显着关联。在成年人中，所有肥胖指数都与哮喘相关，其中中心性肥胖仅在女性中显着。成人的结果是由特应性引起的，尤其是女性。结论：通过双能 X 射线吸收测定法测量的肥胖症提供的信息与通过使用人体测量指数在男女儿童和成年男性中获得的信息相似。然而，双能 X 射线吸收测定法为成年女性提供了额外的信息，其中双能 X 射线吸收测定法测量的中心性肥胖与哮喘，特别是特应性哮喘显着相关。
Rationale: Although obesity has been associated with asthma, body mass index is suboptimal to fully characterize adiposity.Objectives: We examined the relation between adiposity and asthma in a large sample of the U.S. population, using indices defined by dual-energy X-ray absorptiometry.Methods: Weanalyzed data from 8,886 children (aged 8-19 yr) and 12,795 adults (aged 20-69 yr) from the 2001 to 2006 National Health and Nutrition Examination Survey. In addition to body mass index, percent body fat, waist circumference, and waist-to-height ratio, dual-energy X-ray absorptiometry was used to calculate whole-body and local adiposity indices: fat mass index; total, trunk, and legs percent fat; and trunk-to-total fat mass ratio, legs-to-total fat mass ratio, and trunk-to-legs fat mass ratios. Logistic regression was used for the analysis of adiposity measures and asthma.Results: Among children, general adiposity was significantly associated with asthma, with no major differences by sex. Results were driven by nonatopic children, in whom trunk-predominant (central) adiposity (assessed by waist circumference, waist-to-height ratio, trunk-to-total fat mass ratio, and trunk-to-legs fat mass ratio) was also associated with asthma. There were no significant associations among atopic children. Among adults, all adiposity indices were associated with asthma, with central adiposity significant only among women. The results in adults were driven by atopy, especially in women.Conclusions: Adiposity measured by dual-energy X-ray absorptiometry provides similar information to that obtained by using anthropometric indices among children of both sexes and among adult men. However, dual-energy X-ray absorptiometry provides additional information in adult women, in whom dual-energy X-ray absorptiometry-measured central adiposity is significantly associated with asthma, particularly atopic asthma.