Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions
Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions
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DOI：
10.1016/s0959-440x(98)80035-3
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发表时间：
1998-04-01
影响因子：
6.8
通讯作者：
Aebi, U
中科院分区：
文献类型：
--
作者：
Herrmann, H;Aebi, U
中间丝由编码纤维蛋白的多基因家族的一个至几个成员构建，所述纤维蛋白共享高度保守的分层组装计划，用于从结构独特的延伸卷曲螺旋形成多股丝。尽管一级序列同一性相当低，但中间丝就其空间尺寸和物理性质而言形成明显相似的丝。在过去几年中，在阐明中间丝的复杂表达模式和临床相关表型方面取得了实质性进展，然而，这些细丝如何组装以及它们独特的组装中间体的分子结构是什么，还没有得到回答的程度已达到微丝和微管。
Intermediate filaments are built from one to several members of a multigene family encoding fibrous proteins that share a highly conserved hierarchic assembly plan for the formation of multistranded filaments from distinctly structured extended coiled coils. Despite the rather low primary sequence identity, intermediate filaments form apparently similar filaments with regard to their spatial dimensions and physical properties, Over the past few years, substantial progress has been made in the elucidation of the complex expression patterns and clinically relevant phenotypes of intermediate filaments, The key question of how these filaments assemble and what the molecular architecture of their distinct assembly intermediates comprises, however, has still not been answered to the extent that has been achieved for microfilaments and microtubules.