In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children.
In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children.
复制标题
DOI：
10.2337/dc09-0380
复制
发表时间：
2009-11
期刊：
影响因子：
16.2
通讯作者：
Arslanian SA
中科院分区：
文献类型：
--
作者：
Burns SF;Lee S;Arslanian SA
研究性别特异性黑人/白色人脂蛋白谱的差异和内脏肥胖的作用，并评估各组中胰岛素敏感性和脂蛋白谱之间的关系。对226名8 ~<18岁儿童（黑人117名，男性101名）进行了空腹脂蛋白颗粒大小、浓度和内脏脂肪组织（VAT）测定。在194名儿童（100名黑人，88名男性）中评估了脂蛋白和胰岛素敏感性之间的关系，这些儿童接受了高胰岛素-正常血糖钳夹试验。黑人男性儿童的VLDL较小，黑人女性儿童的HDL大于白色儿童。总的来说，黑人的LDL大小较大，没有性别特异性种族差异。在调整VAT和性别后，只有VLDL的大小和浓度在黑人中仍然显著有利。对胰岛素敏感性四分位数的脂蛋白颗粒大小和浓度的分析显示，在两个种族组中，最胰岛素抵抗的儿童比胰岛素敏感的儿童具有更高浓度的小密度LDL、小HDL和大VLDL以及更小的LDL和HDL尺寸。先前报道的黑人儿童与白色儿童的有利脂蛋白谱部分是由于VAT的种族差异。然而，在这两组中，大多数胰岛素抵抗的年轻人具有高风险的致动脉粥样硬化特征，即小密度LDL、小HDL和大VLDL，类似于患有冠状动脉疾病的成年人的致动脉粥样硬化脂蛋白模式。
To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group. Fasting lipoprotein particle size and concentration and visceral adipose tissue (VAT) were determined in 226 children (117 black, 101 male) aged 8 to <18 years. The relationship between lipoproteins and insulin sensitivity was evaluated in a subset of 194 children (100 black, 88 male) who underwent a hyperinsulinemic-euglycemic clamp. Black male children had smaller VLDL and black female children had larger HDL size than their white counterparts. Overall, blacks had larger LDL size with no sex-specific race differences. After adjusting for VAT and sex, only VLDL size and concentrations remained significantly favorable in blacks. Analysis of lipoprotein particle size and concentration across insulin sensitivity quartiles revealed that in both racial groups, the most insulin-resistant children had higher concentrations of small dense LDL, small HDL, and large VLDL and smaller LDL and HDL sizes than their more insulin-sensitive counterparts. The previously reported favorable lipoprotein profiles in black versus white children is partly due to race differences in VAT. In both groups, however, the most insulin-resistant youths have a high-risk atherogenic profile of small dense LDL, small HDL, and large VLDL, akin to the atherogenic lipoprotein pattern in adults with coronary artery disease.