Small leucine-rich proteoglycans in physiological and biomechanical function of bone.
Small leucine-rich proteoglycans in physiological and biomechanical function of bone.
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DOI：
10.1016/j.mbplus.2021.100063
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发表时间：
2021-08
影响因子：
--
通讯作者：
Jiang JX
中科院分区：
文献类型：
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作者：
Hua R;Jiang JX
蛋白聚糖（PG）和糖胺聚糖（GAG）在调节骨稳态的关键信号通路中起重要作用。高度带负电荷的GAG在保持结合水和调节骨的机械性能方面至关重要。PGs、GAGs和结合水的老化相关变化有助于老化过程中骨质量的恶化。蛋白聚糖（PG）含有与核心蛋白连接的长的无分支糖胺聚糖（GAG）链。在骨细胞外基质中，PG代表一类非胶原蛋白，并且对矿物质和胶原具有高亲和力。考虑到GAG的高度带负电荷的特性及其与胶原纤维互连的纤维间定位，PG和GAG在维持基质中的流体静压和渗透压中起关键作用。本文就PGs，尤其是富含亮氨酸的小分子蛋白多糖在调节多种细胞因子和生长因子的生物活性以及骨转换过程中的作用进行综述。此外，我们还重点研究了PGs和GAGs在骨细胞外基质水化状态中的耦合作用，从而调节生理和病理条件下的骨生物力学性能。
Proteoglycans (PGs) and glycosaminoglycans (GAGs) play vital roles in key signaling pathways to regulate bone homeostasis. The highly negatively charged GAGs are crucial in retaining bound water and modulating mechanical properties of bone. Age-related changes of PGs, GAGs, and bound water contribute to deterioration of bone quality during aging. Proteoglycans (PGs) contain long unbranched glycosaminoglycan (GAG) chains attached to core proteins. In the bone extracellular matrix, PGs represent a class of non-collagenous proteins, and have high affinity to minerals and collagen. Considering the highly negatively charged character of GAGs and their interfibrillar positioning interconnecting with collagen fibrils, PGs and GAGs play pivotal roles in maintaining hydrostatic and osmotic pressure in the matrix. In this review, we will discuss the role of PGs, especially the small leucine-rich proteoglycans, in regulating the bioactivity of multiple cytokines and growth factors, and the bone turnover process. In addition, we focus on the coupling effects of PGs and GAGs in the hydration status of bone extracellular matrix, thus modulating bone biomechanical properties under physiological and pathological conditions.