Virology. Epstein-Barr virus turns 50.
Virology. Epstein-Barr virus turns 50.
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DOI：
10.1126/science.1252786
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发表时间：
2014-03-21
期刊：
影响因子：
--
通讯作者：
Lieberman PM
中科院分区：
文献类型：
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作者：
Lieberman PM
本月是第一种人类肿瘤病毒 Epstein-Barr 病毒 (EBV) 发现 50 周年。 1964 年 3 月，安东尼·爱泼斯坦 (Anthony Epstein) 领导的研究小组在源自非洲伯基特淋巴瘤组织的培养肿瘤细胞中发现了疱疹病毒样颗粒。当时，病毒导致人类癌症的观点遭到了一些怀疑，因为癌症具有传染性的理论在上个世纪就被驳回了。坚定的研究人员继续追踪 EBV，直到 20 世纪 90 年代末国际癌症研究机构和世界卫生组织将病毒罪魁祸首宣布为 I 类致癌物。尽管人们一致认为 EBV 是一种真正的肿瘤病毒，但自最初发现 50 年来，EBV 致癌机制仍然是一个活跃研究和争议的领域。
This month marks the 50th anniversary of the discovery of Epstein-Barr virus (EBV) as the first human tumor virus. In March 1964, a team led by Anthony Epstein identified herpesvirus-like particles in cultured tumor cells derived from African Burkitt's lymphoma tissue . At that time, the idea that a virus caused human cancer was met with some skepticism because the theory that cancer was infectious had been dismissed in the previous century. Stalwart investigators continued to track EBV until the viral culprit was declared a class I carcinogen by the International Agency for Research on Cancer and the World Health Organization in the late 1990s. Despite the consensus that EBV is a bona fide tumor virus, the mechanisms of cancer causation by EBV remain an area of active investigation and controversy 50 years since its initial discovery.