The Central Apparatus of Cilia and Eukaryotic Flagella
The Central Apparatus of Cilia and Eukaryotic Flagella
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DOI：
10.1101/cshperspect.a028118
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发表时间：
2017-02-01
影响因子：
7.2
通讯作者：
Smith, Elizabeth F.
中科院分区：
文献类型：
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作者：
Loreng, Thomas D.;Smith, Elizabeth F.
运动纤毛是一种复杂的细胞器，通常由9+2微管骨架组成; 9个双线微管围绕一对中央单线微管。像双微管一样，中心微管形成蛋白质复合物组装的支架，形成相互连接的突起的复杂网络。中央微管和相关结构统称为中央装置（CA）。使用各种实验方法和模式生物的研究已经导致发现了一些高度保守的蛋白质复合物，前所未有的高分辨率投影结构视图，以及对动力蛋白驱动的微管滑动调节的新见解。在这里，我们回顾了最近的进展，在确定机制的组装和功能的CA，包括可能的影响，CA在人类健康中的重要性。
The motile cilium is a complex organelle that is typically comprised of a 9+2 microtubule skeleton; nine doublet microtubules surrounding a pair of central singlet microtubules. Like the doublet microtubules, the central microtubules form a scaffold for the assembly of protein complexes forming an intricate network of interconnected projections. The central microtubules and associated structures are collectively referred to as the central apparatus (CA). Studies using a variety of experimental approaches and model organisms have led to the discovery of a number of highly conserved protein complexes, unprecedented high-resolution views of projection structure, and new insights into regulation of dynein-driven microtubule sliding. Here, we reviewrecent progress in defining mechanisms for the assembly and function of the CA and include possible implications for the importance of the CA in human health.