Insulin sensitivity is inversely correlated with plasma intact parathyroid hormone level
Insulin sensitivity is inversely correlated with plasma intact parathyroid hormone level
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DOI：
10.1053/meta.2000.17708
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发表时间：
2000-11-01
影响因子：
9.8
通讯作者：
Saad, MF
中科院分区：
文献类型：
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作者：
Chiu, KC;Chuang, LM;Saad, MF
据报道，原发性和继发性甲状旁腺功能亢进患者的糖代谢异常和糖尿病的高患病率。我们假设血浆完整甲状旁腺激素（iPTH）水平是胰岛素敏感性或β细胞功能的决定因素。该研究包括52名血压正常、血糖耐受的健康受试者。采用高血糖痉挛法评估胰岛素敏感性和β细胞功能。测定空腹血浆IPTH。观察其水平与胰岛素敏感性指数和β细胞功能的关系。胰岛素敏感性指数与血浆iPTH水平呈负相关（r(2) = 0.104, P = 0.020）。一期胰岛素应答与血浆iPTH水平呈正相关（r(2) = 0.098, P = 0.023），但与二期胰岛素应答无相关性。在调整了年龄、性别、种族和腰臀比后，血浆iPTH水平是胰岛素敏感性指数的独立决定因素（P = 0.019）。然而，血浆iPTH水平与s细胞功能（第一阶段和第二阶段胰岛素反应）之间没有独立的关系。在正常血压、葡萄糖耐受性和健康受试者中，血浆iPTH水平占胰岛素敏感性指数变化的10.4%。血浆iPTH水平每升高pg/mL，胰岛素敏感性指数降低0.247 μ mol/L/m(2)/min/pmol/L。虽然这种关系的分子基础尚不清楚，但我们的研究结果表明血浆iPTH水平与胰岛素敏感性指数呈负相关。版权所有(C) 2000由W.B. Saunders公司。
Abnormal glucose metabolism and a high prevalence of diabetes have been reported in patients with primary and secondary hyperparathyroidism. We hypothesize that plasma intact parathyroid hormone (iPTH) lever is a determinant of either insulin sensitivity or beta -cell function. The study included 52 normotensive, healthy subjects with glucose tolerance. Insulin sensitivity and beta -cell function were assessed using a hyperglycemic cramp. Fasting plasma IPTH was determined. The relationships between its level and insulin sensitivity index and beta -cell function were examined. Insulin sensitivity index was inversely correlated with plasma iPTH level (r(2) = .104, P = .020). The first phase insulin response was positively correlated with plasma iPTH level (r(2) = .098, P = .023), but no correlation existed with the second phase insulin response. After adjusting for age, gender, ethnicity, and waist-to-hip ratio, plasma iPTH level was an independent determinant of insulin sensitivity index (P = .019). However, no independent relationship between plasma iPTH level and S-cell function (the first phase and second phase insulin response) was found. In normotensive, glucose-tolerant, and healthy subjects, plasma iPTH level accounts for 10.4% of the variation in insulin sensitivity index. For each pg/mL increment in plasma iPTH level, there is a decrease of 0.247 mu mol/L/m(2)/min/pmol/L in insulin sensitivity index. Although the molecular basis of this relationship is not clear, our results indicate that plasma iPTH level is inversely correlated with insulin sensitivity index. Copyright (C) 2000 by W.B. Saunders Company.