Copper-Catalyzed N-Arylation with Boronic Acid Pinacol Esters
Copper-Catalyzed N-Arylation with Boronic Acid Pinacol Esters
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铜催化硼酸频哪醇酯的 N-芳基化
DOI：
10.1002/ajoc.201800371
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发表时间：
2018-09-01
影响因子：
2.7
通讯作者：
Xu, Liang
中科院分区：
文献类型：
--
作者：
Liu, Shuai;Xu, Liang
公开了一种铜催化的2-酰基取代苯胺的易n -芳基化。通过弱配位羰基的螯合辅助，在室温下开放烧瓶中进行了Chan-Evans-Lam (CEL) C-N交叉偶联反应。此外，这种螯合作用也使得芳基硼酸松醇酯在温和条件下直接用于cu催化的CEL反应。
A copper-catalyzed facile N-arylation of 2-acyl substituted anilines has been disclosed. Through chelation assistance of the weakly coordinating carbonyl groups, the Chan-Evans-Lam (CEL) C-N cross-coupling reactions proceeded at room temperature in open flasks. Furthermore, such chelation effects also enabled the direct utilization of aryl boronic acid pinacol esters in Cu-catalyzed CEL reactions under mild conditions.