BLOCKING VERSUS CYTOTOXIC ANTIBODY IN HL‐A- AND MIXED LYMPHOCYTE CULTURE‐IDENTICAL AND NONIDENTICAL HUMAN RENAL TRANSPLANT RECIPIENTS
BLOCKING VERSUS CYTOTOXIC ANTIBODY IN HL‐A- AND MIXED LYMPHOCYTE CULTURE‐IDENTICAL AND NONIDENTICAL HUMAN RENAL TRANSPLANT RECIPIENTS
复制标题
HL-A 和混合淋巴细胞培养物中相同和不同的人肾移植受者中的阻断与细胞毒性抗体
DOI：
10.1097/00007890-197507000-00009
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发表时间：
1975
期刊：
影响因子：
6.2
通讯作者：
B. Hattler
中科院分区：
文献类型：
--
作者：
Joshua Miller;J. Lifton;FAYE ROOD;B. Hattler
在未进行脾切除术的肾移植后，已发现在HL-A混合淋巴细胞培养物-相同供体-受体组合中产生针对供体应答细胞的阻断抗体。细胞毒性抗体与排斥反应事件相关，并且仅通过在其他HL-A-混合淋巴细胞培养-相同组合中开发的区分性混合淋巴细胞培养检测到。随着封闭抗体的出现，它消失了，移植后的过程变得平静。此外，在接受两次连续肾移植的患者中，细胞毒性和阻断活性均显示出发展和共存：对供体1的细胞毒性（肾排斥）和对供体2的阻断（肾接受）。这些发现被认为是有利于定性地证明处理两种单独功能的单独抗体分子的有力证据，即，细胞毒性对比增强或免疫调节。
SUMMARY Blocking antibody directed against donor responding cells has been found to develop in HL-A-mixed lymphocyte culture-identical donor-recipient combinations after renal transplantation in which splenectomy was not performed. Cytotoxic antibody associated with rejection episodes and detected only by the discriminatory mixed lymphocyte culture developed in other HL-A-mixed lymphocyte culture-identical combinations as well. It disappeared as blocking antibody appeared and the post-transplant course became uneventful. In addition, both cytotoxic and blocking activity were shown to develop and coexist in a patient who received two successive renal transplants: cytotoxic against donor 1 (kidney rejected), and blocking against donor 2 (kidney accepted). These findings are taken to be strong evidence in favor of qualitatively demonstrable separate antibody molecules dealing with two separate functions, i.e., cytotoxicity versus enhancement or immunoregulation.