MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression.
MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression.
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MicroRNA-506 在胰腺导管腺癌的发展过程中上调，并与疾病进展减弱相关
DOI：
10.1186/s40880-016-0128-9
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发表时间：
2016-07-02
影响因子：
--
通讯作者：
Sun Y
中科院分区：
文献类型：
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作者：
Cheng RF;Wang J;Zhang JY;Sun L;Zhao YR;Qiu ZQ;Sun BC;Sun Y
背景据报道，MicroRNA-506 (miR-506) 在多种肿瘤中作为肿瘤抑制基因或癌基因发挥作用。然而，miR-506在胰腺导管腺癌（PDAC）中的表达和作用仍不清楚。在本研究中，我们旨在评估PDAC中miR-506的表型。方法利用miRNA原位杂交，我们检测了113个PDAC和87对正常胰腺组织中miR-506的表达。我们评估了 PDAC 细胞、正常胰管和腺泡/岛中的 miR-506 表达，并分析了 miR-506 表达与 PDAC 患者临床病理特征之间的关联。结果 PDAC 中的 miR-506 表达高于匹配的正常胰管细胞 (P<0.001)。另一方面，高分化和中分化 PDAC 的组合组显示出比低分化 PDAC 更高的 miR-506 水平 (P= 0.023)。此外，miR-506的表达与病理T类别（P = 0.004）和淋巴结转移（P = 0.033）呈负相关，表明miR-506可能抑制PDAC的进展。结论我们的结果表明，miR-506要么在肿瘤发生中发挥癌基因的作用，在进展中发挥抑癌基因的作用，要么作为看家的、抑制肿瘤的miRNA，其表达可以被抑制。在早期发育过程中被致癌信号激活，阻碍 PDAC 的进展。
BackgroundMicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR-506 in pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we aimed to evaluate the phenotype of miR-506 in PDAC.MethodsUsing miRNA in situ hybridization, we examined the expression of miR-506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated miR-506 expression in PDAC cells, normal pancreatic ducts, and acinus/islands, and we analyzed the associations between miR-506 expression and the clinicopathologic characteristics of PDAC patients.ResultsmiR-506 expression was higher in PDAC than in matched normal pancreatic ductal cells (P< 0.001). On the other hand, the combined group of well and moderately differentiated PDACs showed higher levels of miR-506 than the poorly differentiated ones (P= 0.023). Moreover, miR-506 expression was negatively associated with pathologic T category (P= 0.004) and lymph node metastasis (P= 0.033), suggesting that miR-506 might inhibit the progression of PDAC.ConclusionsOur results suggest that miR-506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house-keeping, tumor-suppressing miRNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.